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Delayed sleep phase syndrome and bipolar disorder: Pathogenesis and available common biomarkers
被引:21
作者:
Talih, Farid
[1
,2
]
Gebara, Nour Y.
[1
]
Andary, Farah S.
[1
]
Mondello, Stefania
[3
,4
]
Kobeissy, Firas
[1
]
Ferri, Raffaele
[4
]
机构:
[1] Amer Univ Beirut, Med Ctr, Fac Med, Beirut, Lebanon
[2] Amer Univ Beirut, Med Ctr, Dept Psychiat, Bldg 56,3rd Floor,POB 110236,Cairo St, Beirut 11072020, Lebanon
[3] Univ Messina, Dept Biomed & Dent Sci & Morphofunct Imaging, Messina, Italy
[4] Oasi Res Inst IRCCS, Sleep Res Ctr, Troina, Italy
关键词:
Circadian rhythm sleep-wake disorders;
Bipolar disorder;
Delayed sleep wake phase disorder;
Biomarkers;
Mood disorder;
Sleep disorders;
Melatonin;
MAJOR DEPRESSIVE DISORDER;
LIGHT MELATONIN ONSET;
CLOCK GENE PER3;
CIRCADIAN-RHYTHMS;
LENGTH POLYMORPHISM;
LOCOMOTOR-ACTIVITY;
BODY-TEMPERATURE;
BRIGHT LIGHT;
I DISORDER;
ASSOCIATION;
D O I:
10.1016/j.smrv.2018.02.002
中图分类号:
R74 [神经病学与精神病学];
学科分类号:
摘要:
Circadian rhythm disturbances are common in bipolar affective disorder (BD). Delayed sleep-wake phase syndrome (DSWPD) is the most prevalent circadian rhythm sleep-wake disorder (CRSWDs) and is frequently observed in BD. It is unclear whether DSWPD in BD is an independent process or is a consequence of BD. In this hypothetical review, we discuss the overlap between BD and DSWPD and potential common biomarkers for DSWPD and BD. The review will include a discussion of the genetics of DSWPD and BD. Biomarkers elucidating the pathophysiological processes occurring in these two disorders may offer insight into the etiology and prognosis of both conditions. (c) 2018 Elsevier Ltd. All rights reserved.
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页码:133 / 140
页数:8
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