Cerebral MRI abnormalities in a premature infant with later confirmed congenital central hypoventilation syndrome

被引：0

作者：

van Delft, Eveline ^{[1
]}

Andriessen, Peter ^{[1
]}

Vaessens, Colleen N. A. L. ^{[2
]}

Buijs, Jan ^{[1
]}

Oetomo, Sidarto Bambang ^{[1
,3
]}

机构：

[1] Maxima Med Ctr, Dept Neonatol, NL-5500 MB Veldhoven, Netherlands

[2] Elkerliek Hosp, Dept Pediat, Helmond, Netherlands

[3] Eindhoven Univ Technol, Dept Ind Design, NL-5600 MB Eindhoven, Netherlands

来源：

EUROPEAN JOURNAL OF PEDIATRICS | 2010年 / 169卷 / 07期

关键词：

Congenital central hypoventilation syndrome; Ondine's curse; MRI; Premature; PHOX2B MUTATIONS; BRAIN-STEM; GENETICS; DISEASE;

D O I：

10.1007/s00431-009-1112-z

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

We present a premature infant with an inability to ventilate spontaneously during sleep periods. In addition, the patient showed general hypotonia. The child had a delayed passage of stool and increased anal muscle tone, indicating Hirschsprung's disease. The combination of these symptoms suggested congenital central hypoventilation syndrome, which was confirmed postmortem by DNA analysis showing a mutation in the PHOX2B gene. MRI of the brain showed damage to the white matter, including the internal capsula. This type of damage to the white matter has not been described before in a premature infant, who did not experience birth asphyxia.

引用

页码：895 / 898

页数：4

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