Time-to-pregnancy and risk of schizophrenia

被引：7

作者：

Opler, Mark G. A. ^{[1
,2
]}

Harlap, Susan ^{[1
,4
,5
]}

Ornstein, Katherine ^{[3
]}

Kleinhaus, Karine ^{[1
,4
,5
]}

Perrin, Mary ^{[1
,4
]}

Gangwisch, James E. ^{[2
]}

Lichtenberg, Pesach ^{[6
,7
]}

Draiman, Benjamin ^{[6
,7
]}

Malaspina, Dolores ^{[1
,2
,4
]}

机构：

[1] NYU, Sch Med, NYU Med Ctr, InSPIRES,Dept Psychiat, New York, NY 10016 USA

[2] Columbia Univ, Dept Psychiat, Coll Phys & Surg, New York, NY USA

[3] Columbia Univ, Dept Epidemiol, Mailman Sch Publ Hlth, New York, NY USA

[4] NYU, Dept Environm Med, Sch Med, New York, NY 10016 USA

[5] NYU, Dept Obstet & Gynecol, Sch Med, New York, NY 10016 USA

[6] Hebrew Univ Jerusalem, Herzog Hosp, IL-91905 Jerusalem, Israel

[7] Hebrew Univ Jerusalem, Hadassah Med Sch, IL-91905 Jerusalem, Israel

来源：

SCHIZOPHRENIA RESEARCH | 2010年 / 118卷 / 1-3期

基金：

美国国家卫生研究院;

关键词：

Time-to-pregnancy; Fecundability; Paternal age; Schizophrenia; ADVANCED PATERNAL AGE; PARENTAL AGE; REPRODUCTIVE FUNCTION; FERTILITY; COHORT; MUTATION; INFERTILITY; POPULATION; DISORDERS; DISEASE;

D O I：

10.1016/j.schres.2010.01.013

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Schizophrenia has been linked to advanced paternal age, but the explanation is unknown. We questioned whether the incidence of schizophrenia would be related to male reproductive capacity, as reflected in the time taken to conceive. We measured the incidence of schizophrenia in relation to time to conception in a sub-group of 12,269 in the Jerusalem cohort whose mothers, interviewed post-partum, reported that the pregnancy had been intended. Compared with those conceived in less than 3 months, the unadjusted relative risks (RR) of schizophrenia associated with conception-waits of 3-5, 6-11 and 12+ months were 1.10 (95% confidence interval, 0.62-1.94), 1.41 (0.79-2.52) and 1.88 (1.05-3.37) with p for trend = 0.035. This trend was attenuated somewhat by adjusting for paternal age, and was observed more strongly in offspring of fathers aged 30+ (p=.010). These findings suggest that factors associated with fecundability, either male or female, may contribute to the risk of schizophrenia. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：76 / 80

页数：5

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