Identification of a phytotoxic photo-transformation product of diclofenac using effect-directed analysis

被引：61
作者：
Schulze, Tobias [1 ]
Weiss, Sara [1 ,3 ]
Schymanski, Emma [1 ]
von der Ohe, Peter Carsten [1 ]
Schmitt-Jansen, Mechthild [2 ]
Altenburger, Rolf [2 ]
Streck, Georg [1 ]
Brack, Werner [1 ]
机构：
[1] UFZ Helmholtz Ctr Environm Res, Dept Effect Directed Anal, D-04318 Leipzig, Germany
[2] UFZ Helmholtz Ctr Environm Res, Dept Bioanalyt Ecotoxicol, D-04318 Leipzig, Germany
[3] Fraunhofer Inst Toxicol & Expt Med, Dept Chem Risk Assessment, D-30625 Hannover, Germany
来源：
ENVIRONMENTAL POLLUTION | 2010年 / 158卷 / 05期
关键词：
Diclofenac; 2-[2-(Chlorophenyl)amino]benzaldehyde; Effect-directed analysis; Photo-transformation; Scenedesmus vacuolatus; MODELKEY; PHARMACEUTICAL DRUG DICLOFENAC; ORGANIC TOXICANTS; WATER; TOXICITY; PHOTODEGRADATION; RIVER; ECOTOXICOLOGY; CLASSIFIERS; IBUPROFEN; RISK;
D O I：
10.1016/j.envpol.2009.12.032
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
The pharmaceutical diclofenac (DCF) is released in considerably high amounts to the aquatic environment. Photo-transformation of DCF was reported as the main degradation pathway in surface waters and was found to produce metabolites with enhanced toxicity to the green algae Scenedesmus vacuolatus. We identified and subsequently confirmed 2-[2-(chlorophenyl)amino]benzaldehyde (CPAB) as a transformation product with enhanced toxicity using effect-directed analysis. The EC50 of CPAB (4.8 mg/L) was a factor of 10 lower than that for DCF (48.1 mg/L), due to the higher hydrophobicity of CPAB (log K-ow = 3.62) compared with DCF (log D-ow = 2.04) at pH 7.0. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1461 / 1466
页数：6
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