Portal Inflow Modulation by Somatostatin After Major Liver Resection: A Pilot Study

被引：26

作者：

Rhaiem, Rami ^{[1
,2
]}

Piardi, Tullio ^{[1
,2
]}

Chetboun, Mikael ^{[1
,2
]}

Pessaux, Patrick ^{[3
]}

Lestra, Thibaut ^{[2
,4
]}

Memeo, Riccardo ^{[3
]}

Kianmanesh, Reza ^{[1
,2
]}

Sommacale, Daniele ^{[1
,2
]}

机构：

[1] Robert Debre Univ Hosp, Dept Gen Digest & Endocrine Surg, Ave Gen Koenig, F-51100 Reims, France

[2] Univ Champagne Ardennes, Reims, France

[3] Univ Hosp Strasbourg, Hepatobiliary & Pancreat Surg Unit, Nouvel Hop Civil, Strasbourg, France

[4] Robert Debre Univ Hosp, Radiol Dept, Reims, France

来源：

ANNALS OF SURGERY | 2018年 / 267卷 / 06期

关键词：

FOR-SIZE SYNDROME; VENOUS-PRESSURE; TRANSPLANTATION; GRAFT; HYPERTENSION; HEPATECTOMY; MORTALITY; LIGATION;

D O I：

10.1097/SLA.0000000000002601

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Major hepatectomy (MH) can lead to an increasing portal vein pressure (PVP) and to lesions of the hepatic parenchyma. Several reports have assessed the deleterious effect of a high posthepatectomy PVP on the postoperative course of MH. Thus, several surgical modalities of portal inflow modulation (PIM) have been described. As for pharmacological modalities, experimental studies showed a potential efficiency of Somatostatin to reduce PVP and flow. To our knowledge, no previous clinical reports of PIM using somatostatin are available. Herein, we report the results of PIM using somatostatin in 10 patients who underwent MH with post-hepatectomy PVP > 20 mmHg. Our results suggest Somatostatin could be considered as an efficient reversible PIM when PVP decrease is above 2.5 mmHg.

引用

页码：E101 / E103

页数：3

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