Meta Selective C-H Borylation of Sterically Biased and Unbiased Substrates Directed by Electrostatic Interaction

被引：75

作者：

Chaturvedi, Jagriti ^{[1
,2
]}

Haldar, Chabush ^{[1
]}

Bisht, Ranjana ^{[1
]}

Pandey, Gajanan ^{[2
]}

Chattopadhyay, Buddhadeb ^{[1
]}

机构：

[1] Ctr Biomed Res, Div Mol Synth & Drug Discovery, Lucknow 226014, Uttar Pradesh, India

[2] Babasaheb Bhimrao Ambedkar Univ, Dept Appl Chem, Lucknow 226025, Uttar Pradesh, India

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2021年 / 143卷 / 20期

关键词：

ACTIVATION; ARENES; LIGAND; AROMATICS;

D O I：

10.1021/jacs.1c01770

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An electrostatically directed meta borylation of sterically biased and unbiased substrates is described. The borylation follows an electrostatic interaction between the partially positive and negative charges between the ligand and substrate. With this strategy, it has been demonstrated that a wide number of challenging substrates, especially 4-substituted substrates, can selectively be borylated at the meta position. Moreover, unsubstituted substrates also displayed excellent meta selectivity. The reaction employs a bench-stable ligand and proceeds at a milder temperature, precluding the need to synthesize a bulky and sophisticated ligand/template.

引用

页码：7604 / 7611

页数：8

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