Redox-responsive cisplatin nanogels for anticancer drug delivery

被引：44
|
作者：
Zhang, Weiqi [1 ]
Tung, Ching-Hsuan [1 ]
机构：
[1] Cornell Univ, Weill Cornell Med, Mol Imaging Innovat Inst, Dept Radiol, 413 East 69th St,Box 290, New York, NY 10021 USA
来源：
CHEMICAL COMMUNICATIONS | 2018年 / 54卷 / 60期
关键词：
CANCER CELLS; GLUTATHIONE; RESISTANCE; PLATINUM; NANOPARTICLES; DOXORUBICIN;
D O I：
10.1039/c8cc01795f
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Inspired by cisplatin's deactivation by glutathione (GSH) in cancer, a GSH responsive nanogel loaded with doxorubicin (Dox) was prepared using hyaluronan as a matrix and cisplatin as a crosslinker. The elevated GSH depletes the cisplatin crosslinker in the nanogel, enhances Dox release and boosts cytotoxicity, thus providing a new GSH responsive platform to reverse cisplatin resistance.
引用
收藏
页码：8367 / 8370
页数：4
相关论文
共 50 条
  • [41] Redox-Responsive Hyaluronic Acid-Based Nanogels for the Topical Delivery of the Visual Chromophore to Retinal Photoreceptors
    Laradji, Amine M.
    Kolesnikov, Alexander, V
    Karakocak, Bedia B.
    Kefalov, Vladimir J.
    Ravi, Nathan
    ACS OMEGA, 2021, 6 (09): : 6172 - 6184
  • [42] Redox-Responsive Biomimetic Polymeric Micelle for Simultaneous Anticancer Drug Delivery and Aggregation-Induced Emission Active Imaging
    Hu, Jun
    Zhuang, Weihua
    Ma, Boxuan
    Su, Xin
    Yu, Tao
    Li, Gaocan
    Hu, Yanfei
    Wang, Yunbing
    BIOCONJUGATE CHEMISTRY, 2018, 29 (06) : 1897 - 1910
  • [43] Redox-responsive degradable prodrug nanogels for intracellular drug delivery by crosslinking of amine-functionalized poly(N-vinylpyrrolidone) copolymers
    Peng, Huan
    Huang, Xiaobin
    Melle, Andrea
    Karperien, Marcel
    Pich, Andrij
    JOURNAL OF COLLOID AND INTERFACE SCIENCE, 2019, 540 : 612 - 622
  • [44] Stimulus responsive nanogels for drug delivery
    Zha, Liusheng
    Banik, Brittany
    Alexis, Frank
    SOFT MATTER, 2011, 7 (13) : 5908 - 5916
  • [45] Fabrication Of Dual pH/redox-Responsive Lipid-Polymer Hybrid Nanoparticles For Anticancer Drug Delivery And Controlled Release
    Men, Wanfu
    Zhu, Peiyao
    Dong, Siyuan
    Liu, Wenke
    Zhou, Kun
    Bai, Yu
    Liu, Xiangli
    Gong, Shulei
    Zhang, Can Yang
    Zhang, Shuguang
    INTERNATIONAL JOURNAL OF NANOMEDICINE, 2019, 14 : 8001 - 8011
  • [46] Redox-responsive nanocapsules for intracellular protein delivery
    Zhao, Muxun
    Biswas, Anuradha
    Hu, Biliang
    Joo, Kye-Il
    Wang, Pin
    Gu, Zhen
    Tang, Yi
    BIOMATERIALS, 2011, 32 (22) : 5223 - 5230
  • [47] Controlling Morphologies of Redox-Responsive Polymeric Nanocarriers for a Smart Drug Delivery System
    Lee, Chae Gyu
    Kwon, Tae-Hyuk
    CHEMISTRY-A EUROPEAN JOURNAL, 2023, 29 (34)
  • [48] Dual pH- and Redox-responsive Chitosan Nanoparticles as Drug Delivery Carriers
    Xu, Chuang
    Wang, Xiao-ju
    Wang, Chen-hong
    Yan, Hu-sheng
    Liu, Ke-liang
    ACTA POLYMERICA SINICA, 2015, (01): : 65 - 71
  • [49] Novel Redox-Responsive Amphiphilic Copolymer Micelles for Drug Delivery: Synthesis and Characterization
    Bae, Jungeun
    Maurya, Abhijeet
    Shariat-Madar, Zia
    Murthy, S. Narasimha
    Jo, Seongbong
    AAPS JOURNAL, 2015, 17 (06): : 1357 - 1368
  • [50] Redox-responsive micelles for triggered drug delivery and effective laryngopharyngeal cancer therapy
    Sun, Changling
    Li, Xiaoying
    Du, Xiaodong
    Wang, Teng
    INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2018, 112 : 65 - 73
12345