Redox-responsive cisplatin nanogels for anticancer drug delivery

被引：44
|
作者：
Zhang, Weiqi [1 ]
Tung, Ching-Hsuan [1 ]
机构：
[1] Cornell Univ, Weill Cornell Med, Mol Imaging Innovat Inst, Dept Radiol, 413 East 69th St,Box 290, New York, NY 10021 USA
来源：
CHEMICAL COMMUNICATIONS | 2018年 / 54卷 / 60期
关键词：
CANCER CELLS; GLUTATHIONE; RESISTANCE; PLATINUM; NANOPARTICLES; DOXORUBICIN;
D O I：
10.1039/c8cc01795f
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Inspired by cisplatin's deactivation by glutathione (GSH) in cancer, a GSH responsive nanogel loaded with doxorubicin (Dox) was prepared using hyaluronan as a matrix and cisplatin as a crosslinker. The elevated GSH depletes the cisplatin crosslinker in the nanogel, enhances Dox release and boosts cytotoxicity, thus providing a new GSH responsive platform to reverse cisplatin resistance.
引用
收藏
页码：8367 / 8370
页数：4
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