Neural Responses to BEGIN- and END-Stimuli of the Smoking Ritual in Nonsmokers, Nondeprived Smokers, and Deprived Smokers

被引:49
作者
Stippekohl, Bastian [1 ]
Winkler, Markus [2 ]
Mucha, Ronald F. [2 ]
Pauli, Paul [2 ]
Walter, Bertram [1 ]
Vaitl, Dieter [1 ]
Stark, Rudolf [1 ]
机构
[1] Univ Giessen, Bender Inst Neuroimaging, D-35394 Giessen, Hessen, Germany
[2] Univ Wurzburg, Dept Psychol, D-97070 Wurzburg, Germany
关键词
addiction; smoking; cue reactivity; fMRI; deprivation; terminal stimuli; ANTERIOR CINGULATE CORTEX; STRIATUM/NUCLEUS ACCUMBENS ACTIVATION; BEHAVIOR SYSTEMS-APPROACH; ADDICTED HUMAN BRAIN; EVENT-RELATED FMRI; DRUG-ADDICTION; CUE-REACTIVITY; CONDITIONED INHIBITION; ORBITOFRONTAL CORTEX; NICOTINE ABSTINENCE;
D O I
10.1038/npp.2009.227
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Drug-associated stimuli (cues) have a prominent role in addiction research because they are able to provoke craving and relapses. Generally, drug cues are seen as conditioned excitatory stimuli, which elicit drug seeking and usage. However, newer data suggest differential effects for smoking stimuli depending on their stage in the smoking ritual. Specifically, stimuli associated with the terminal stage of smoke consumption (END-stimuli) may evoke reactivity opposite to the reactivity evoked by stimuli associated with the beginning of smoke consumption (BEGIN-stimuli). This fMRI study compared 20 nondeprived smokers with 20 nonsmokers to unravel the influence of smoking-related pictures displaying the beginning (BEGIN-stimuli) and termination (END-stimuli) of the smoking ritual on neural activity in the addiction network. In addition, 20 deprived smokers (12 h deprivation) were investigated to explore the effects of deprivation on the processing of these stimuli. In nondeprived smokers, BEGIN-stimuli reliably activated the addiction network (for example, the ventral striatum, orbitofrontal cortex, and anterior cingulate cortex (ACC)). In contrast, END-stimuli triggered a differential pattern of activations as well as deactivations; deactivations were found in the ventral striatum and the ACC. Deprivation had no clear effect on the responses triggered by BEGIN-stimuli, but affected the reactivity to END-stimuli. Our data clearly suggest that stimuli associated with different stages of the smoking ritual trigger differential neuronal responses. While BEGIN-stimuli generally seem to activate the addiction network, END-stimuli presumably have some inhibitory properties. This new finding might add to a more differentiated understanding of cue reactivity and addiction. Neuropsychopharmacology (2010) 35, 1209-1225; doi: 10.1038/npp.2009.227; published online 20 January 2010
引用
收藏
页码:1209 / 1225
页数:17
相关论文
共 89 条
[11]   Cisplatin and gemcitabine in non-small-cell lung cancer [J].
Cartei, G ;
Sacco, C ;
Sibau, A ;
Pella, N ;
Iop, A ;
Tabaro, G .
ANNALS OF ONCOLOGY, 1999, 10 :57-62
[12]   Meta-analysis of cue-reactivity in addiction research [J].
Carter, BL ;
Tiffany, ST .
ADDICTION, 1999, 94 (03) :327-340
[13]   The cue-availability paradigm: The effects of cigarette availability on cue reactivity in smokers [J].
Carter, BL ;
Tiffany, ST .
EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY, 2001, 9 (02) :183-190
[14]   Limbic activation during cue-induced cocaine craving [J].
Childress, AR ;
Mozley, PD ;
McElgin, W ;
Fitzgerald, J ;
Reivich, M ;
O'Brien, CP .
AMERICAN JOURNAL OF PSYCHIATRY, 1999, 156 (01) :11-18
[15]   How do you feel - now? The anterior insula and human awareness [J].
Craig, A. D. .
NATURE REVIEWS NEUROSCIENCE, 2009, 10 (01) :59-70
[16]   Changes in regional cerebral blood flow elicited by craving memories in abstinent opiate-dependent subjects [J].
Daglish, MRC ;
Weinstein, A ;
Malizia, AL ;
Wilson, S ;
Melichar, JK ;
Britten, S ;
Brewer, C ;
Lingford-Hughes, A ;
Myles, JS ;
Grasby, P ;
Nutt, DJ .
AMERICAN JOURNAL OF PSYCHIATRY, 2001, 158 (10) :1680-1686
[17]   Effects of Acute Nicotine Abstinence on Cue-elicited Ventral Striatum/Nucleus Accumbens Activation in Female Cigarette Smokers: A Functional Magnetic Resonance Imaging Study [J].
David, Sean P. ;
Munafo, Marcus R. ;
Johansen-Berg, Heidi ;
MacKillop, James ;
Sweet, Lawrence H. ;
Cohen, Ronald A. ;
Niaura, Raymond ;
Rogers, Robert D. ;
Matthews, Paul M. ;
Walton, Robert T. .
BRAIN IMAGING AND BEHAVIOR, 2007, 1 (3-4) :43-57
[18]   Ventral striatum/nucleus accumbens activation to smoking-related pictorial cues in smokers and nonsmokers:: A functional magnetic resonance imaging study [J].
David, SP ;
Munafò, MR ;
Johansen-Berg, H ;
Smith, SM ;
Rogers, RD ;
Matthews, PM ;
Walton, RT .
BIOLOGICAL PSYCHIATRY, 2005, 58 (06) :488-494
[19]  
Della Casa V, 1999, J PSYCHOPHARMACOL, V13, P45
[20]   CONTRIBUTIONS OF ANTERIOR CINGULATE CORTEX TO BEHAVIOUR [J].
DEVINSKY, O ;
MORRELL, MJ ;
VOGT, BA .
BRAIN, 1995, 118 :279-306