The effects of 5-HT1A and 5-HT2C receptor agonists on behavioral satiety sequence in rats

被引：33

作者：

Elsa Lopez-Alonso, Veronica ^{[1
]}

Manuel Mancilla-Diaz, Juan ^{[1
]}

Rito-Domingo, Melissa ^{[1
]}

Gonzalez-Hernandez, Brenda ^{[1
]}

Erick Escartin-Perez, Rodrigo ^{[1
]}

机构：

[1] Univ Nacl Autonoma Mexico, Neurobiol Eating Lab, FES Iztacala, Tlalnepantla 54090, Mexico

来源：

NEUROSCIENCE LETTERS | 2007年 / 416卷 / 03期

关键词：

5-HT1A receptor; 5-HT2C receptor; serotonergic system; behavioral satiety sequence; food intake;

D O I：

10.1016/j.neulet.2007.02.026

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The present study examined the effects of 5-HT1A and 5-HT2C receptor agonists on behavioral satiety sequence (BSS) in rats. The 5-HT1A receptor agonist, 8-OH-DPAT (0.5 mu g), and the 5-HT2C receptor agonist, Ro-60-0175 (3.0 mu g), were injected into the paraventricular nucleus (PVN) of rats. The animals were maintained on an ad libitum feeding paradigm with access to water and individual sources of protein, carbohydrate, and fat. Intra-PVN administration of each agonist was associated with decreased carbohydrate consumption. The effect was enhanced by the administration of both agonists together. Behavioral analysis indicated that co-administration of 8-OH-DPAT and Ro-60-0175 interrupted the natural BSS with an increase in non-feeding behavior, whereas the 8-OH-DPAT alone promoted early development of the natural BSS. In conclusion, the 5-HT receptor agonists affected serotonergic modulation of feeding behavior in a functionally selective way. (c) 2007 Elsevier Ireland Ltd. All rights reserved.

引用

页码：285 / 288

页数：4

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