SMALL FIBER NEUROPATHY IN FEMALE PATIENTS WITH FABRY DISEASE

被引：44

作者：

Liguori, Rocco ^{[1
]}

Di Stasi, Vitantonio ^{[1
]}

Bugiardini, Enrico ^{[1
]}

Mignani, Renzo ^{[2
]}

Burlina, Alessandro ^{[3
]}

Borsini, Walter ^{[4
]}

Baruzzi, Agostino ^{[1
]}

Montagna, Pasquale ^{[1
]}

Donadio, Vincenzo ^{[1
]}

机构：

[1] Univ Bologna, Dipartimento Sci Neurol, I-40123 Bologna, Italy

[2] Infermi Hosp, Dept Nephrol, Rimini, Italy

[3] S Bassiano Hosp, Dept Neurol, Bassano Del Grappa Vi, Bassano, Italy

[4] Careggi Hosp, Dept Neurol, Florence, Italy

来源：

MUSCLE & NERVE | 2010年 / 41卷 / 03期

关键词：

small fiber neuropathy; skin biopsy; autonomic dysfunction; Fabry disease; female; INNERVATION;

D O I：

10.1002/mus.21606

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Recent studies suggest that heterozygous female Fabry disease (FD) patients develop peripheral neuropathy. We used skin biopsy to define somatic and autonomic peripheral nerve characteristics in 21 females with FD who were mainly asymptomatic and had normal renal function. Somatic epidermal and dermal autonomic nerve fiber reductions were found, prevalently in the leg, and no differences were found between symptomatic and asymptomatic individuals. Our findings suggest that females with FD, although asymptomatic, may have somatic and autonomic small fiber neuropathy. Muscle Nerve 41: 409-412, 2010

引用

页码：409 / 412

页数：4

共 9 条

[1] Skin sympathetic adrenergic innervation: An immunofluorescence confocal study [J].