Relationship between dietary factors and S-Klotho plasma levels in young sedentary healthy adults

被引：16

作者：

Jurado-Fasoli, Lucas ^{[1
,2
]}

Amaro-Gahete, Francisco J. ^{[1
,2
,3
]}

Arias-Tellez, Maria J. ^{[1
,2
,4
]}

Gil, Angel ^{[5
,6
,7
,8
,9
]}

Labayen, Idoia ^{[10
]}

Ruiz, Jonatan R. ^{[1
]}

机构：

[1] Univ Granada, PROmoting FITness & Hlth Phys Act Res Grp PROFITH, Sport & Hlth Univ Res Inst iMUDS, Dept Phys Educ & Sports,Fac Sport Sci, Granada 18071, Spain

[2] Univ Granada, EFFECTS Res Grp 262, Dept Med Physiol, Sch Med, Granada 18071, Spain

[3] Camilo Jose Cela Univ, Dept Hlth, Madrid, Spain

[4] Univ Chile, Fac Med, Dept Nutr, Independence 1027, Santiago, Chile

[5] Univ Granada, Dept Biochem & Mol Biol 2, Granada 18071, Spain

[6] Iberoamer Nutr Fdn FINUT, Av Conocimiento 12,3a Pta, Granada 18016, Spain

[7] Univ Granada, Biomed Res Ctr, Inst Nutr & Food Technol Jose Mataix, Parque Tecnol Salud,Ave Conocimiento S-N, Granada 18100, Spain

[8] Inst Invest Biosanit Granada Ibs GRANADA, Granada, Spain

[9] Inst Salud Carlos III ISCIII, CIBEROBN Physiopathol Obes & Nutr CB12 03 30038, Madrid 28029, Spain

[10] Univ Publ Navarra, Inst Innovat & Sustainable Dev Food Chain IS Food, Campus Arrosadia, Pamplona 31008, Spain

来源：

MECHANISMS OF AGEING AND DEVELOPMENT | 2021年 / 194卷

关键词：

Diet; Dietary inflammatory index; Alcohol; Aging; Lean mass; Uric acid; DENSITY-LIPOPROTEIN CHOLESTEROL; ALCOHOL METABOLISM; GENDER-DIFFERENCES; URIC-ACID; GENE; DISEASE; MOUSE; RISK; EXPRESSION; REDUCTION;

D O I：

10.1016/j.mad.2021.111435

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Objective: To study the associations of dietary factors with S-Klotho plasma levels in young adults. We also aimed to study whether body composition and cardiometabolic risk factors affected the association between dietary factors and S-Klotho plasma levels. Methods: A total of 139 young adults took part in this study. Dietary factors were measured using a food frequency questionnaire and three non-consecutive 24 h recalls. S-Klotho plasma levels were measured by immunosorbent assay. Body composition was measured by DXA. Results: We observed a direct association of ethanol intake and S-Klotho plasma levels in women. An inverse association was also observed between the dietary inflammatory index (DII) with S-Klotho plasma levels in all sample. No mediation effects of body composition or cardiometabolic risk factors were observed in the relationship between alcohol and S-Klotho plasma levels. Lean mass index (LMI) and uric acid levels mediated the relationship between DII and S-Klotho plasma levels. Conclusion: A pro-inflammatory dietary pattern was inversely associated with S-Klotho plasma levels in young adults, which was partially mediated by LMI and uric acid levels.

引用

页数：9

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