Metal-organic framework-based intelligent drug delivery systems for cancer theranostic: A review

被引：12
作者：
Xu, Qingni [1 ]
Li, Chaohua [1 ]
Chen, Yuqi [1 ]
Zhang, Yueli [1 ]
Lu, Bo [1 ]
机构：
[1] Wuhan Univ Technol, Sch Chem Chem Engn & Life Sci, Wuhan 430070, Hubei, Peoples R China
来源：
FRONTIERS OF MATERIALS SCIENCE | 2021年 / 15卷 / 03期
基金：
中国国家自然科学基金;
关键词：
metal-organic framework; nanomaterial; stimuli-responsiveness; cancer theranostic; MESOPOROUS SILICA NANOPARTICLES; PHOTODYNAMIC THERAPY; TUMOR; RELEASE; GSH; NANOPLATFORM; CHEMOTHERAPY; LIPOSOMES; PH; NANOCOMPOSITES;
D O I：
10.1007/s11706-021-0568-2
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
The design and development of multifunctional nano-drug delivery systems (NDDSs) is a solution that is expected to solve some intractable problems in traditional cancer treatment. In particular, metal-organic frameworks (MOFs) are novel hybrid porous nanomaterials which are constructed by the coordination of metal cations or clusters and organic bridging ligands. Benefiting from their intrinsic superior properties, MOFs have captivated intensive attentions in drug release and cancer theranostic. Based on what has been achieved about MOF-based DDSs in recent years, this review introduces different stimuli-responsive mechanisms of them and their applications in cancer diagnosis and treatment systematically. Moreover, the existing challenges and future opportunities in this field are summarized. By realizing industrial production and paying attention to biosafety, their clinical applications will be enriched.
引用
收藏
页码：374 / 390
页数：17
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