Enzymatically Asymmetrised Chiral Building Blocks for the Synthesis of Complex Natural Product Analogues: The Synthesis of Dynemicin Analogues from 2-(Quinolin-4-yl)propane-1,3-diol

被引：3

作者：

Riva, Renata ^{[1
]}

Banfi, Luca ^{[1
]}

Basso, Andrea ^{[1
]}

Gandolfo, Valentina ^{[1
]}

Guanti, Giuseppe ^{[1
]}

机构：

[1] Univ Genoa, Dept Chem & Ind Chem, I-16146 Genoa, Italy

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2010年 / 2010卷 / 14期

关键词：

Antitumor agents; Diastereoselectivity; Nitrogen heterocycles; Alkynes; Enediynes; ANTITUMOR-ACTIVITY; BIOLOGICAL EVALUATION; GLYCEROL DERIVATIVES; ENEDIYNES; CHEMISTRY; LIPASE; DESIGN; ACID; UNCIALAMYCIN; ENANTIOMERS;

D O I：

10.1002/ejoc.200901478

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Full details of our synthetic approaches directed towards the enantioselective synthesis of new dynemicin analogues each containing a side-arm (a "handle") incorporating a protected alcohol are reported.

引用

页码：2768 / 2787

页数：20

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