Losartan and its interaction with copper(II): Biological effects

被引：30

作者：

Etcheverry, Susana B.

Ferrer, Evelina G.

Naso, Luciana

Barrio, Daniel A.

Lezama, Luis

Rojo, Tefilo

Williams, Patricia A. M. ^{[1
]}

机构：

[1] Univ Nacl La Plata, Fac Ciencias Exactas, Ctr Quim Inorgan, La Plata, Argentina

[2] Univ Nacl La Plata, Fac Ciencias Exactas, Catedra Bioquim Patol, La Plata, Argentina

[3] Univ Basque Country, Fac Ciencias & Tecnol, Dept Quim Inorgan, E-48080 Bilbao, Spain

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2007年 / 15卷 / 19期

关键词：

antiltypertensive; losartan; copper complex; biological activities;

D O I：

10.1016/j.bmc.2007.06.056

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Losartan, the potassium salt of 2-n-butyl-4-chloro-5-hydroxymethyl-1-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]imi-dazol, is an efficient antihypertensive drug. The vibrational FTIR and Raman spectra of Losartan (its anionic and protonated forms) are discussed. In addition, the copper(II) complex of Losartan was obtained and characterized as a microcrystalline powder. The metal center is bound to the ligand through the nitrogen atoms of the tetrazolate moiety as determined by vibrational spectroscopy. The compound is a dimer with the metal centers in a tetragonal distorted environment but the presence of a monomeric impurity has been determined by EPR spectroscopy. The antioxidant properties of the complex (superoxide dismutase mimetic activity) and its effect on the proliferation and morphology of two osteoblast-like cells in culture are reported. The new compound exerted more toxic effects on tumoral cells than the copper(II) ion and Losartan. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：6418 / 6424

页数：7

共 39 条

[1] Reinvestigation of the copper(Il)-carcinine equilibrium system: "two-dimensional" EPR simulation and NMR relaxation studies for determining the formation constants and coordination modes [J].