Acquired hemophilia A: a review of recent data and new therapeutic options

被引：85

作者：

Franchini, Massimo ^{[1
,2
]}

Vaglio, Stefania ^{[1
,3
]}

Marano, Giuseppe ^{[1
]}

Mengoli, Carlo ^{[1
]}

Gentili, Sara ^{[1
]}

Pupella, Simonetta ^{[1
]}

Liumbruno, Giancarlo Maria ^{[1
]}

机构：

[1] Natl Inst Hlth, Italian Natl Blood Ctr, Rome, Italy

[2] Carlo Poma Hosp, Dept Haematol & Transfus Med, Mantua, Italy

[3] Sapienza Univ Rome, Dept Clin & Mol Med, Rome, Italy

来源：

HEMATOLOGY | 2017年 / 22卷 / 09期

关键词：

Acquired hemophilia A; factor VIII; bleeding; eradication therapy; FACTOR-VIII INHIBITORS; ACTIVATED FACTOR-VII; TRANSFUSION MANAGEMENT; EXTRACORPOREAL IMMUNOADSORPTION; COAGULATION INHIBITORS; RANDOMIZED-TRIAL; PORCINE SEQUENCE; RECOMBINANT; RECOMMENDATIONS; DIAGNOSIS;

D O I：

10.1080/10245332.2017.1319115

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objectives: Acquired hemophilia A (AHA) is a rare, but potentially life-threatening, bleeding disorder caused by an autoantibody against factor VIII that interferes with its coagulant function. Methods: We performed a narrative review focusing on the diagnostic aspects of AHA and on the current treatment strategies with particular regard to new data and therapeutic developments. Results: The management of this severe hemorrhagic disorder is based on the control of bleeding with the use of bypassing agents and on the utilization of a variety of immunosuppressant agents with the goal of eliminating the autoantibody permanently. Conclusion: The optimal management of AHA should be multidisciplinary and requires a close collaboration between physicians from various specialties.

引用

页码：514 / 520

页数：7

共 76 条

[71]

Toschi V, 2010, CURR OPIN MOL THER, V12, P617

[72] Recommendations for the implementation of a Patient Blood Management programme. Application to elective major orthopaedic surgery in adults [J].

Vaglio, Stefania ;

Prisco, Domenico ;

Biancofiore, Gianni ;

Rafanelli, Daniela ;

Antonioli, Paola ;

Lisanti, Michele ;

Andreani, Lorenzo ;

Basso, Leonardo ;

Velati, Claudio ;

Grazzini, Giuliano ;

Liumbruno, Giancarlo M. .

BLOOD TRANSFUSION, 2016, 14 (01) :23-65

[73]

VERBRUGGEN B, 1995, THROMB HAEMOSTASIS, V73, P247

[74] Diagnostic and prognostic value of factor VIII binding antibodies in acquired hemophilia A: data from the GTH-AH 01/2010 study [J].

Werwitzke, S. ;

Geisen, U. ;

Nowak-Goettl, U. ;

Eichler, H. ;

Stephan, B. ;

Scholz, U. ;

Holstein, K. ;

Klamroth, R. ;

Knoebl, P. ;

Huth-Kuehne, A. ;

Bomke, B. ;

Tiede, A. .

JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2016, 14 (05) :940-947

[75] Treatment of acquired hemophilia by the Bonn-Malmo Protocol: documentation of an in vivo immunomodulating concept [J].

Zeitler, H ;

Ulrich-Merzenich, G ;

Hess, L ;

Konsek, E ;

Unkrig, C ;

Walger, P ;

Vetter, H ;

Brackmann, HH .

BLOOD, 2005, 105 (06) :2287-2293

[76] The relevance of the bleeding severity in the treatment of acquired haemophilia - an update of a single-centre experience with 67 patients [J].

Zeitler, H. ;

Ulrich-Merzenich, G. ;

Goldmann, G. ;

Vidovic, N. ;

Brackmann, H. H. ;

Oldenburg, J. .

HAEMOPHILIA, 2010, 16 :95-101

← 1 2 3 4 5 6 7 8 →