Evaporative Cooling Hydrogel Packaging for Storing Biologics Outside of the Cold Chain

被引：25

作者：

Ferber, Shiran ^{[1
]}

Behrens, Adam M. ^{[1
]}

McHugh, Kevin J. ^{[1
]}

Rosenberg, Evan M. ^{[1
]}

Linehan, Allison R. ^{[1
]}

Sugarman, James L. ^{[1
]}

Jayawardena, Hapuarachchige Surangi N. ^{[1
]}

Langer, Robert ^{[1
]}

Jaklenec, Ana ^{[1
]}

机构：

[1] MIT, David H Koch Inst Integrat Canc Res, 500 Main St, Cambridge, MA 02139 USA

来源：

ADVANCED HEALTHCARE MATERIALS | 2018年 / 7卷 / 14期

关键词：

biologics; cold chains; hydrogels; packaging; storage; TRANSFER RADICAL POLYMERIZATION; THERMAL INACTIVATION; CELL-CULTURE; FILMS; VACCINE; DELIVERY; TRANSITION; ROBUST; GELS;

D O I：

10.1002/adhm.201800220

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Stabilizing thermolabile pharmaceuticals outside of the cold chain has the potential to alleviate some of the logistical and monetary burden of providing health care access in the developing world. Evaporative cooling hydrogel packaging is designed to extend the storage stability of existing pharmaceutical products without the need for reformulation. Hydrogels with high water content and reversible hydrophilicity offer a promising platform for reducing storage temperatures without refrigeration. As a model, poly(N-isopropylacrylamide) is selected as a basis for creating a potentially low cost and easy-to-fabricate hydrogels.

引用

页数：6

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