Gas chromatography-mass spectrometric assay for propofol in cerebrospinal fluid of traumatic brain patients

被引：8
作者：
Peeters, Mariska Y. M.
Kuiper, Hiltjo
Greijdanus, Ben
van der Naalt, Joukje
Knibbe, Catherijne A. J.
Uges, Donald R. A.
机构：
[1] St Antonius Hosp, Dept Clin Pharm, NL-3430 EM Nieuwegein, Netherlands
[2] Univ Groningen, Med Ctr, Dept Pharm, Lab Clin & Forens Toxicol & Drug Anal, Groningen, Netherlands
[3] Univ Groningen, Med Ctr, Dept Neurol, Groningen, Netherlands
[4] Leiden Univ, Div Pharmacol, Leiden Amsterdam Ctr Drug Res, NL-2300 RA Leiden, Netherlands
来源：
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES | 2007年 / 852卷 / 1-2期
关键词：
propofol; CSF; GC-MS;
D O I：
10.1016/j.jchromb.2007.01.001
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
A sensitive gas chromatography-mass spectrometry method for measuring propofol in cerebrospinal fluid is described, validated and applied to four patients after traumatic brain injury. The limit of quantitation was 2 mu g/L using a volume of 0.5 mL. The inter- and intra-assay coefficients of variation were 5.9 and 5.1%, respectively. The assay covers the linear concentration range of 2-50 mu g/L, which is relevant in clinical pharmacokinetic studies when propofol is used in the Intensive Care Unit as a sedative agent or to lower the intracranial pressure. (c) 2007 Elsevier B.V. All rights reserved.
引用
收藏
页码：635 / 639
页数：5
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