Ganglionic acetylcholine receptor autoantibodies in patients with autoimmune diseases including primary biliary cirrhosis

被引：19

作者：

Maeda, Yasuhiro ^{[1
,2
,3
]}

Nakane, Shunya ^{[1
,2
]}

Higuchi, Osamu ^{[1
]}

Nakamura, Hideki ^{[4
]}

Komori, Atsumasa ^{[5
,6
]}

Migita, Kiyoshi ^{[5
]}

Mukaino, Akihiro ^{[7
,8
]}

Umeda, Masataka ^{[4
]}

Ichinose, Kunihiro ^{[4
]}

Tamai, Mami ^{[4
]}

Kawashiri, Shin-ya ^{[9
]}

Sakai, Waka ^{[2
]}

Yatsuhashi, Hiroshi ^{[5
,6
]}

Kawakami, Atsushi ^{[4
]}

Matsuo, Hidenori ^{[2
]}

机构：

[1] Natl Hosp Org Nagasaki Kawatana Med Ctr, Dept Clin Res, Nagasaki, Japan

[2] Natl Hosp Org Nagasaki Kawatana Med Ctr, Dept Neurol, Nagasaki, Japan

[3] Nagasaki Univ, Grad Sch Biomed Sci, Dept Neuroimmunol, Nagasaki, Japan

[4] Nagasaki Univ, Grad Sch Biomed Sci, Dept Immunol & Rheumatol, Nagasaki, Japan

[5] Natl Hosp Org Nagasaki Med Ctr, Dept Clin Res, Nagasaki, Japan

[6] Natl Hosp Org Nagasaki Med Ctr, Dept Hepatol, Nagasaki, Japan

[7] Nagasaki Univ Hosp, Dept Neurol & Strokol, Nagasaki, Japan

[8] Nagasaki Univ, Grad Sch Biomed Sci, Dept Internal Med 1, Nagasaki, Japan

[9] Nagasaki Univ, Grad Sch Biomed Sci, Dept Publ Hlth, Nagasaki, Japan

来源：

MODERN RHEUMATOLOGY | 2017年 / 27卷 / 04期

关键词：

Anti-ganglionic acetylcholine receptor antibodies; Primary biliary cirrhosis; Rheumatoid arthritis; Systemic lupus erythematosus; Systemic sclerosis; SYSTEMIC-LUPUS-ERYTHEMATOSUS; RHEUMATOID-ARTHRITIS; REVISED CRITERIA; IMMUNOGENETICS; CLASSIFICATION; DYSFUNCTION;

D O I：

10.1080/14397595.2016.1226469

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objectives: Autonomic dysfunction is closely associated with autoimmune diseases (AID) including primary biliary cirrhosis (PBC). The objective of this study was to determine the prevalence of anti-ganglionic (nicotinic) acetylcholine receptor (gAChR) antibodies in patients with AID. Methods: We determined the presence of gAChR antibodies in serum samples from 146 patients (systemic lupus erythematosus [SLE]=32; rheumatoid arthritis [RA]=43; systemic sclerosis [SSc]=38; PBC=33) without information regarding autonomic symptoms, as well as 34 patients with other neurological diseases [OND], and 73 healthy controls [HC]. We specifically analyzed sera for anti-gAChR3 and -4 antibodies using the luciferase immunoprecipitation system (LIPS) assay. Results: LIPS assay detected anti-gAChR3 and -4 antibodies in the sera from patients with SLE (12.5%, 4/32), RA (18.6%, 8/43), SSc (13.2%, 5/38), PBC (9.1%, 3/33), OND (2.9%, 1/34), and HC (0.0%, 1/73). There were no significant correlations between the levels of anti-gAChR3 and -4 antibodies, and the total titers of autoantibodies in AID. Conclusions: The results demonstrated a significant prevalence of anti-gAChR antibodies in patients with AID, which is independent of the production of other autoantibodies in patients with autoimmune diseases. These anti-gAChR antibodies could mediate the autonomic dysfunction involved in the autoimmune mechanisms of AID.

引用

页码：664 / 668

页数：5

共 18 条

[1] Autonomic function and rheumatoid arthritis-A systematic review [J].

Adlan, Ahmed M. ;

Lip, Gregory Y. H. ;

Paton, Julian F. R. ;

Kitas, George D. ;

Fisher, James P. .

SEMINARS IN ARTHRITIS AND RHEUMATISM, 2014, 44 (03) :283-304

[2] PRELIMINARY CRITERIA FOR THE CLASSIFICATION OF SYSTEMIC-SCLEROSIS (SCLERODERMA) [J].

不详 .

ARTHRITIS AND RHEUMATISM, 1980, 23 (05) :581-590

[3] THE AMERICAN-RHEUMATISM-ASSOCIATION 1987 REVISED CRITERIA FOR THE CLASSIFICATION OF RHEUMATOID-ARTHRITIS [J].

ARNETT, FC ;

EDWORTHY, SM ;

BLOCH, DA ;

MCSHANE, DJ ;

FRIES, JF ;

COOPER, NS ;

HEALEY, LA ;

KAPLAN, SR ;

LIANG, MH ;

LUTHRA, HS ;

MEDSGER, TA ;

MITCHELL, DM ;

NEUSTADT, DH ;

PINALS, RS ;

SCHALLER, JG ;

SHARP, JT ;

WILDER, RL ;

HUNDER, GG .

ARTHRITIS AND RHEUMATISM, 1988, 31 (03) :315-324

[4] Heart rate turbulence assessment in systemic sclerosis: the role for the detection of cardiac autonomic nervous system dysfunction [J].

Bienias, Piotr ;

Ciurzynski, Michal ;

Glinska-Wielochowska, Maria ;

Szewczyk, Agnieszka ;

Korczak, Dariusz ;

Kalinska-Bienias, Agnieszka ;

Glinski, Wieslaw ;

Pruszczyk, Piotr .

RHEUMATOLOGY, 2010, 49 (02) :355-360

[5] Immunogenetics of systemic lupus erythematosus: A comprehensive review [J].

Ghodke-Puranik, Yogita ;

Niewold, Timothy B. .

JOURNAL OF AUTOIMMUNITY, 2015, 64 :125-136

[6] Autoimmune autonomic ganglionopathy with Sjogren's syndrome: Significance of ganglionic acetylcholine receptor antibody and therapeutic approach [J].

Kondo, Takayuki ;

Inoue, Haruhisa ;

Usui, Takashi ;

Mimori, Tsuneyo ;

Tomimoto, Hidekazu ;

Vernino, Steven ;

Takahashi, Ryosuke .

AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL, 2009, 146 (1-2) :33-35

[7] Primary Biliary Cirrhosis [J].

Lindor, Keith D. ;

Gershwin, M. Eric ;

Poupon, Raoul ;

Kaplan, Marshall ;

Bergasa, Nora V. ;

Heathcote, E. Jenny .

HEPATOLOGY, 2009, 50 (01) :291-308

[8] Association between Anti-Ganglionic Nicotinic Acetylcholine Receptor (gAChR) Antibodies and HLA-DRB1 Alleles in the Japanese Population [J].

Maeda, Yasuhiro ;

Migita, Kiyoshi ;

Higuchi, Osamu ;

Mukaino, Akihiro ;

Furukawa, Hiroshi ;

Komori, Atsumasa ;

Nakamura, Minoru ;

Hashimoto, Satoru ;

Nagaoka, Shinya ;

Abiru, Seigo ;

Yatsuhashi, Hiroshi ;

Matsuo, Hidenori ;

Kawakami, Atsushi ;

Yasunami, Michio ;

Nakane, Shunya .

PLOS ONE, 2016, 11 (01)

[9]

Mukaino A, 2016, MOD RHEUMATOL

[10] Clinical Features of Autoimmune Autonomic Ganglionopathy and the Detection of Subunit-Specific Autoantibodies to the Ganglionic Acetylcholine Receptor in Japanese Patients [J].

Nakane, Shunya ;

Higuchi, Osamu ;

Koga, Michiaki ;

Kanda, Takashi ;

Murata, Kenya ;

Suzuki, Takashi ;

Kurono, Hiroko ;

Kunimoto, Masanari ;

Kaida, Ken-ichi ;

Mukaino, Akihiro ;

Sakai, Waka ;

Maeda, Yasuhiro ;

Matsuo, Hidenori .

PLOS ONE, 2015, 10 (03)

← 1 2 →