Melanopsin: An opsin in melanophores, brain, and eye

被引:710
作者
Provencio, I
Jiang, GS
De Grip, WJ
Hayes, WP
Rollag, MD
机构
[1] Uniformed Serv Univ Hlth Sci, Dept Anat & Cell Biol, Bethesda, MD 20814 USA
[2] Univ Nijmegen, Inst Cellular Signaling, NL-6500 HB Nijmegen, Netherlands
[3] Catholic Univ Amer, Dept Biol, Washington, DC 20064 USA
关键词
D O I
10.1073/pnas.95.1.340
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
We have identified an opsin, melanopsin, in photosensitive dermal melanophores of Xenopus laevis. Its deduced amino acid sequence shares greatest homology with cephalopod opsins, The predicted secondary structure of melanopsin indicates the presence of a long cytoplasmic tail with multiple putative phosphorylation sites, suggesting that this opsin's function may be finely regulated, Melanopsin mRNA is expressed in hypothalamic sites thought to contain deep brain photoreceptors and in the iris, a structure known to be directly photosensitive in amphibians. Melanopsin message is also localized in retinal cells residing in the outermost lamina of the inner nuclear layer where horizontal cells are typically found, Its expression in retinal and nonretinal tissues suggests a role in vision and nonvisual photoreceptive tasks, such as photic control of skin pigmentation, pupillary aperture, and circadian and photoperiodic physiology.
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页码:340 / 345
页数:6
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