Case Series of Pleomorphic Carcinoma of the Lung Treated With Immune Checkpoint Inhibitors

被引：7

作者：

Hayashi, Kana ^{[1
]}

Tokui, Kotaro ^{[1
]}

Inomata, Minehiko ^{[1
]}

Azechi, Kenji ^{[1
]}

Mizushima, Isami ^{[1
]}

Takata, Naoki ^{[1
]}

Taka, Chihiro ^{[1
]}

Okazawa, Seisuke ^{[1
]}

Kambara, Kenta ^{[1
]}

Imanishi, Shingo ^{[1
]}

Miwa, Toshiro ^{[1
]}

Hayashi, Ryuji ^{[2
]}

Matsui, Shoko ^{[1
]}

Nomura, Satoshi ^{[3
]}

Tobe, Kazuyuki ^{[1
]}

机构：

[1] Toyama Univ Hosp, Dept Internal Med 1, Sugitani 2630, Toyama 9300194, Japan

[2] Toyama Univ Hosp, Dept Med Oncol, Toyama, Japan

[3] Toyama City Hosp, Resp Med, Toyama, Japan

来源：

IN VIVO | 2021年 / 35卷 / 03期

关键词：

Immune checkpoint inhibitor; pembrolizumab; pleomorphic carcinoma; sarcomatoid carcinoma; PROGRESSION-FREE SURVIVAL; PALLIATIVE CHEMOTHERAPY; NIVOLUMAB; DOCETAXEL; OUTCOMES;

D O I：

10.21873/invivo.12428

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Aim: We report, herein, three cases of pleomorphic carcinoma of the lung treated with immune checkpoint inhibitors. Case 1: A 73-year-old man was diagnosed as having pleomorphic carcinoma of the lung and treated with pembrolizumab alone. However, he showed no response and died 4 months after the initiation of the treatment. Case 2: A 66-year-old man was diagnosed as having pleomorphic carcinoma of the lung. He was started on a combination regimen of pembrolizumab plus carboplatin plus nabpaclitaxel, and a remarkable response was observed. Case 3: A 49-year-old man was diagnosed as having pleomorphic carcinoma of the lung. He was started on pembrolizumab monotherapy as second-line treatment. Eleven months after the treatment initiation, computed tomography revealed the decrease of tumor diameter. Conclusion: Immune checkpoint inhibitor therapy is expected to improve the prognosis of patients with pleomorphic carcinoma of the lung.

引用

页码：1687 / 1692

页数：6

共 27 条

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