Anti-nociceptive and anti-inflammatory activity of some (2-benzoxazolone-3-yl and 2-benzothiazolone-3-yl)acetic acid derivatives

被引：74

作者：

Dogruer, DS

Unlu, S

Sahin, MF ^{[1
]}

Yesilada, E

机构：

[1] Gazi Univ, Fac Pharm, Dept Pharmaceut Chem, TR-06330 Ankara, Turkey

[2] Gazi Univ, Fac Pharm, Dept Pharmacognosy, TR-06330 Ankara, Turkey

来源：

FARMACO | 1998年 / 53卷 / 01期

关键词：

anti-nociceptive activity; anti-inflammatory activity; benzoxazolinone derivatives; benzothiazolinone derivatives;

D O I：

10.1016/S0014-827X(97)00017-7

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Sixteen (2-benzothiazolone-3-yl and 2-benzoxazolone-3-yl)acetic acid derivatives 5 have been tested for anti-nociceptive and antiinflammatory activity in this study. 4-[2-(6-Benzoyl-2-benzoxazolone-3-yl)acetyl] morpholine (5c),4-{2-[6-(2-chloro-benzoyl)-2-benzoxazolone-3-yl]acetyl} -morpholine (5d), 1-[2-(5-chloro-2-benzoxazolone-3-yl)acetyl]pyrrolidine (5f), methyl (6-methyl-2-benzoxazolone-3-yl)acetate (5k) and N,N-diethyl-2-(2-benzothiazolone-3-yl)acetamide (5m) have shown more potent anti-nociceptive activity than others. Among these compounds, 5c, 5d and 5m have exhibited good anti-inflammatory activity, with 5f, and to a lesser extent, the other molecules displaying some toxic potential. (C) 1998 Elsevier Science S.A.

引用

页码：80 / 84

页数：5

共 20 条

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