Interaction between nitric oxide synthase inhibitor induced oscillations and the activation flow coupling response

被引:8
作者
Ances, Beau M. [1 ]
Greenberg, Joel H. [2 ,3 ]
Detre, John A. [2 ,3 ]
机构
[1] Washington Univ, Dept Neurol, St Louis, MO 63110 USA
[2] Univ Penn, Dept Neurol, Philadelphia, PA 19104 USA
[3] Univ Penn, Cerebrovasc Res Ctr, Philadelphia, PA 19104 USA
关键词
Nitric oxide; Oscillation; Laser Doppler flowmetry and Cerebral blood flow; CEREBRAL-BLOOD-FLOW; LOW-FREQUENCY OSCILLATIONS; LASER-DOPPLER FLOWMETRY; SOMATOSENSORY STIMULATION; FUNCTIONAL HYPEREMIA; NERVOUS-SYSTEM; BRAIN MICROCIRCULATION; VIBRISSAL STIMULATION; ARTERIOLAR VASOMOTION; NEURONAL ACTIVATION;
D O I
10.1016/j.brainres.2009.09.119
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The role of nitric oxide (NO) in the activation-flow coupling (AFC) response to periodic electrical forepaw stimulation was investigated using signal averaged laser Doppler (LD) flowmetry. LD measures of calculated cerebral blood flow (CBF) were obtained both prior and after intra-peritoneal administration of the non-selective nitric oxide synthase (NOS) inhibitor, N-G-nitro-L-arginine (L-NNA) (40 mg/kg). Characteristic baseline low frequency vasomotion oscillations (0.17 Hz) were observed after L-NNA administration. These LDCBF oscillations were synchronous within but not between hemispheres. L-NNA reduced the magnitude of the AFC response (p < 0.05) for longer stimuli (I min) with longer inter-stimulus intervals (2 min). in contrast, the magnitude of the AFC response for short duration stimuli (4 s) with short inter-stimulus intervals (20 s) was augmented (p < 0.05) after L-NNA. An interaction occurred between L-NNA induced vasomotion oscillations and the AFC response with the greatest increase occurring at the stimulus harmonic closest to the oscillatory frequency. Nitric oxide may therefore modulate the effects of other vasodilators involved in vasomotion oscillations and the AFC response. (C) 2009 Elsevier B.V. All rights reserved.
引用
收藏
页码:19 / 28
页数:10
相关论文
共 55 条
[1]   INCREASES IN LOCAL CEREBRAL BLOOD-FLOW ASSOCIATED WITH SOMATOSENSORY ACTIVATION ARE NOT MEDIATED BY NO [J].
ADACHI, K ;
TAKAHASHI, S ;
MELZER, P ;
CAMPOS, KL ;
NELSON, T ;
KENNEDY, C ;
SOKOLOFF, L .
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 1994, 267 (06) :H2155-H2162
[2]   NITRIC-OXIDE (NO) IS INVOLVED IN INCREASED CEREBRAL CORTICAL BLOOD-FLOW FOLLOWING STIMULATION OF THE NUCLEUS BASALIS OF MEYNERT IN ANESTHETIZED RATS [J].
ADACHI, T ;
INANAMI, O ;
SATO, A .
NEUROSCIENCE LETTERS, 1992, 139 (02) :201-204
[3]   Transcranial laser doppler mapping of activation flow coupling of the rat somatosensory cortex [J].
Ances, BM ;
Detre, JA ;
Takahashi, K ;
Greenberg, JH .
NEUROSCIENCE LETTERS, 1998, 257 (01) :25-28
[4]   L-NA-sensitive rCBF augmentation during vibrissal stimulation in type III nitric oxide synthase mutant mice [J].
Ayata, C ;
Ma, JY ;
Meng, W ;
Huang, P ;
Moskowitz, MA .
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1996, 16 (04) :539-541
[5]   Coupling arterial windkessel with peripherial vasomotion: Modeling the effects on low-frequency oscillations [J].
Baselli, G ;
Porta, A ;
Pagani, M .
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 2006, 53 (01) :53-64
[6]   An arteriolar compliance model of the cerebral blood flow response to neural stimulus [J].
Behzadi, Y ;
Liu, TT .
NEUROIMAGE, 2005, 25 (04) :1100-1111
[7]   Fine detail of neurovascular coupling revealed by spatiotemporal analysis of the hemodynamic response to single whisker stimulation in rat barrel cortex [J].
Berwick, J. ;
Johnston, D. ;
Jones, M. ;
Martindale, J. ;
Martin, C. ;
Kennerley, A. J. ;
Redgrave, P. ;
Mayhew, J. E. W. .
JOURNAL OF NEUROPHYSIOLOGY, 2008, 99 (02) :787-798
[8]   Synchronous oscillations in cerebrocortical capillary red blood cell velocity after nitric oxide synthase inhibition [J].
Biswal, BB ;
Hudetz, AG .
MICROVASCULAR RESEARCH, 1996, 52 (01) :1-12
[9]   NITRIC-OXIDE SYNTHASE BLOCKADE ENHANCES VASOMOTION IN THE CEREBRAL MICROCIRCULATION OF ANESTHETIZED RATS [J].
DIRNAGL, U ;
LINDAUER, U ;
VILLRINGER, A .
MICROVASCULAR RESEARCH, 1993, 45 (03) :318-323
[10]   CONTINUOUS MEASUREMENT OF CEREBRAL CORTICAL BLOOD-FLOW BY LASER-DOPPLER FLOWMETRY IN A RAT STROKE MODEL [J].
DIRNAGL, U ;
KAPLAN, B ;
JACEWICZ, M ;
PULSINELLI, W .
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1989, 9 (05) :589-596