CD56 Expression Marks Human Group 2 Innate Lymphoid Cell Divergence from a Shared NK Cell and Group 3 Innate Lymphoid Cell Developmental Pathway

被引：85

作者：

Chen, Luxi ^{[1
,2
]}

Youssef, Youssef ^{[3
]}

Robinson, Cameron ^{[2
]}

Ernst, Gabrielle F. ^{[2
]}

Carson, Mary Y. ^{[2
]}

Young, Karen A. ^{[3
]}

Scoville, Steven D. ^{[1
,2
]}

Zhang, Xiaoli ^{[4
]}

Harris, Regine ^{[2
]}

Sekhri, Palak ^{[2
]}

Mansour, Anthony G. ^{[2
]}

Chan, Wing K. ^{[2
,5
]}

Nalin, Ansel P. ^{[1
,2
]}

Mao, Hsiaoyin C. ^{[2
]}

Hughes, Tiffany ^{[2
]}

Mace, Emily M. ^{[6
]}

Pan, Yinghong ^{[7
]}

Rustagi, Navin ^{[7
]}

Chatterjee, Sujash S. ^{[7
]}

Gunaratne, Preethi H. ^{[7
]}

Behbehani, Gregory K. ^{[2
,5
]}

Mundy-Bosse, Bethany L. ^{[2
,5
]}

Caligiuri, Michael A. ^{[8
]}

Freud, Aharon G. ^{[3
,5
]}

机构：

[1] Ohio State Univ, James Canc Hosp, Med Scientist Training Program, Biomed Sci Grad Program, Columbus, OH 43210 USA

[2] Ohio State Univ, James Canc Hosp, Dept Internal Med, Div Hematol, Columbus, OH 43210 USA

[3] Ohio State Univ, James Canc Hosp, Dept Pathol, Columbus, OH 43210 USA

[4] Ohio State Univ, James Canc Hosp, Ctr Biostat, Columbus, OH 43210 USA

[5] Ohio State Univ, James Canc Hosp, Comprehens Canc Ctr, Columbus, OH 43210 USA

[6] Columbia Univ, Dept Pediat, New York, NY 10027 USA

[7] Univ Houston, Dept Biol & Biochem, Houston, TX 77204 USA

[8] City Hope Natl Med Ctr, Duarte, CA 91010 USA

来源：

IMMUNITY | 2018年 / 49卷 / 03期

基金：

美国国家卫生研究院;

关键词：

MASS CYTOMETRY; DIFFERENTIATION; IDENTIFICATION; PROGENITOR; SUBSET; HETEROGENEITY; PRECURSORS; GENERATION; RESPONSES; RECEPTOR;

D O I：

10.1016/j.immuni.2018.08.010

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

According to the established model of murine innate lymphoid cell (ILC) development, helper ILCs develop separately from natural killer (NK) cells. However, it is unclear how helper ILCs and NK cells develop in humans. Here we elucidated key steps of NK cell, ILC2, and ILC3 development within human tonsils using ex vivo molecular and functional profiling and lineage differentiation assays. We demonstrated that while tonsillar NK cells, ILC2s, and ILC3s originated from a common CD34(+)CD117(+) ILC precursor pool, final steps of ILC2 development deviated independently and became mutually exclusive from those of NK cells and ILC3s, whose developmental pathways overlapped. Moreover, we identified a CD34(-)CD117(+) ILC precursor population that expressed CD56 and gave rise to NK cells and ILC3s but not to ILC2s. These data support a model of human ILC development distinct from the mouse, whereby human NK cells and ILC3s share a common developmental pathway separate from ILC2s.

引用

页码：464 / +

页数：17

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