Current Standard and Future Perspectives in the Treatment of Gastrointestinal Stromal Tumors

被引：17

作者：

Cameron, Silke ^{[1
]}

Beham, Alexander ^{[2
]}

Schildhaus, Hans-Ulrich ^{[3
]}

机构：

[1] Univ Med, Clin Gastroenterol & Gastrointestinal Oncol, Gottingen, Germany

[2] Univ Med, Clin Gastrointestinal Visceral & Pediat Surg, Gottingen, Germany

[3] Univ Med, Inst Pathol, Gottingen, Germany

来源：

DIGESTION | 2017年 / 95卷 / 04期

关键词：

Gastrointestinal stromal tumors; Tyrosine kinase inhibitors; Diagnosis and treatment; ADJUVANT IMATINIB MESYLATE; INTERSTITIAL-CELLS; ACTIVATING MUTATIONS; BRAF MUTATIONS; GIST; KIT; CAJAL; TRIAL; RISK; PATHOLOGY;

D O I：

10.1159/000455835

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The origin of gastrointestinal stromal tumors (GIST) from interstitial cells of Cajal or their precursor cells has been understood since the early 1990s. The first mutations within the KIT-gene have been described in the late 1990s. Even though these mutations were the breakthrough of small molecular therapy, we still do not know the factors responsible for their malignant transformation. Until then, we can only speak of recurrence risk. This review gives an introduction on the current understanding of GIST and highlights the remaining questions for diagnosis, tumor progression, and treatment in progressive disease. (C) 2017 S. Karger AG, Basel.

引用

页码：262 / 268

页数：7

共 50 条

[1] Gastrointestinal Stromal Tumours (GIST) - development in pathology, surgery and medical therapy Developed during the 10th German GIST-meeting, Gottingen [J].

Agaimy, A. ;

Bauer, S. ;

Beham, A. ;

Bertolini, J. ;

Haller, F. ;

Koschny, R. ;

Maier, J. ;

Montemurro, M. ;

Perez, D. ;

Schaefer, I-M ;

Schildhaus, H-U ;

Wurst, C. ;

Cameron, S. .

ZEITSCHRIFT FUR GASTROENTEROLOGIE, 2015, 53 (03) :235-243

[2] Hereditary and non-hereditary syndromic gastointestinal stromal tumours [J].

Agaimy, A. ;

Hartmann, A. .

PATHOLOGE, 2010, 31 (06) :430-+

[3] V600E BRAF mutations are alternative early molecular events in a subset of KIT/PDGFRA wild-type gastrointestinal stromal tumours [J].

Agaimy, A. ;

Terracciano, L. M. ;

Dirnhofer, S. ;

Tornillo, L. ;

Foerster, A. ;

Hartmann, A. ;

Bihl, M. P. .

JOURNAL OF CLINICAL PATHOLOGY, 2009, 62 (07) :613-616

[4]

Agaimy A, 2010, INT J CLIN EXP PATHO, V3, P461

[5] Molecular characterization of pediatric gastrointestinal stromal tumors [J].

Agaram, Narasimhan P. ;

Laquaglia, Michael P. ;

Ustun, Berrin ;

Guo, Tianhua ;

Wong, Grace C. ;

Socci, Nicholas D. ;

Maki, Robert G. ;

DeMatteo, Ronald P. ;

Besmer, Peter ;

Antonescu, Cristina R. .

CLINICAL CANCER RESEARCH, 2008, 14 (10) :3204-3215

[6]

[Anonymous], 2014, ANN ONCOL S3, V25, piii21

[7]

[Anonymous], 2013, ASCO Meeting Abstracts, V31, P10500

[8] Overexpression of insulin-like growth factor 1 receptor and frequent mutational inactivation of SDHA in wild-type SDHB-negative gastrointestinal stromal tumors [J].

Belinsky, Martin G. ;

Rink, Lori ;

Flieder, Douglas B. ;

Jahromi, Mona S. ;

Schiffman, Joshua D. ;

Godwin, Andrew K. ;

von Mehren, Margaret .

GENES CHROMOSOMES & CANCER, 2013, 52 (02) :214-224

[9] Gastrointestinal stromal tumours:: Consensus statement on diagnosis and treatment [J].

Blackstein, ME ;

Blay, JY ;

Corless, C ;

Driman, DK ;

Riddell, R ;

Soulières, D ;

Swallow, CJ ;

Verma, S .

CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2006, 20 (03) :157-163

[10]

Cameron S, 2009, Minerva Gastroenterol Dietol, V55, P409

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