The role of extracellular vesicle microRNAs in cancer biology

被引：106

作者：

Takahashi, Ryou-u ^{[2
]}

Prieto-Vila, Marta ^{[2
]}

Hironaka, Ai ^{[2
]}

Ochiya, Takahiro ^{[1
]}

机构：

[1] Natl Canc Ctr, Res Inst, Div Mol & Cellular Med, Chuo Ku, 1-1,Tsukiji 5 Chome, Tokyo 1040045, Japan

[2] Natl Canc Ctr, Res Inst, Div Mol & Cellular Med, Tokyo, Japan

来源：

CLINICAL CHEMISTRY AND LABORATORY MEDICINE | 2017年 / 55卷 / 05期

关键词：

biomarker; cancer; diagnosis; exosome; microRNA; therapy; TO-MESENCHYMAL TRANSITION; SQUAMOUS-CELL CARCINOMA; BREAST-CANCER; RECIPIENT CELLS; OVARIAN-CANCER; LUNG-CANCER; MULTIVESICULAR BODIES; PROMOTE METASTASIS; PANCREATIC-CANCER; DRUG-RESISTANCE;

D O I：

10.1515/cclm-2016-0708

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

microRNAs (miRNAs) constitute a large family of small, approximately 20-22 nucleotide non-coding RNAs that regulate the expression of target genes, mainly at the post-transcriptional level. Multiple studies report that miRNAs are involved in homeostatic maintenance and that aberrant expression of miRNAs is often observed in various types of diseases, including cancer. In cancer biology, miRNAs exert functional roles in tumor initiation, drug resistance, and metastasis. miRNAs are also secreted through small vesicles called exosomes, which are endosome-derived vesicles derived from various cell types including immune and tumor cells. In addition to cellular miRNAs (ce-miRNAs), secreted miRNAs (se-miRNAs) play important roles in cancer development and metastasis. Therefore, se-miRNAs in body fluids have been investigated as a promising biomarkers and therapeutic targets for cancer treatment. In this review, we summarize the current knowledge of miRNA functions in cancer development and discuss the potential clinical applications of se-miRNAs, e.g. as diagnostic markers and therapeutic targets.

引用

页码：648 / 656

页数：9

共 86 条

[41] Neutral Sphingomyelinase 2 (nSMase2)-dependent Exosomal Transfer of Angiogenic MicroRNAs Regulate Cancer Cell Metastasis [J].

Kosaka, Nobuyoshi ;

Iguchi, Haruhisa ;

Hagiwara, Keitaro ;

Yoshioka, Yusuke ;

Takeshita, Fumitaka ;

Ochiya, Takahiro .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2013, 288 (15) :10849-10859

[42] Combined determination of circulating miR-196a and miR-196b levels produces high sensitivity and specificity for early detection of oral cancer [J].

Lu, Ya-Ching ;

Chang, Joseph Tung-Chieh ;

Huang, Yu-Chen ;

Huang, Chi-Che ;

Chen, Wen-Ho ;

Lee, Li-Yu ;

Huang, Bing-Shen ;

Chen, Yin-Ju ;

Li, Hsiao-Fang ;

Cheng, Ann-Joy .

CLINICAL BIOCHEMISTRY, 2015, 48 (03) :115-121

[43] Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration [J].

Luga, Valbona ;

Zhang, Liang ;

Viloria-Petit, Alicia M. ;

Ogunjimi, Abiodun A. ;

Inanlou, Mohammad R. ;

Chiu, Elaine ;

Buchanan, Marguerite ;

Hosein, Abdel Nasser ;

Basik, Mark ;

Wrana, Jeffrey L. .

CELL, 2012, 151 (07) :1542-1556

[44] Nuclear export of microRNA precursors [J].

Lund, E ;

Güttinger, S ;

Calado, A ;

Dahlberg, JE ;

Kutay, U .

SCIENCE, 2004, 303 (5654) :95-98

[45] Effect of miR-155 knockdown on the reversal of doxorubicin resistance in human lung cancer A549/dox cells [J].

Lv, Lixia ;

An, Xiumei ;

Li, Hongyan ;

Ma, Lanxiu .

ONCOLOGY LETTERS, 2016, 11 (02) :1161-1166

[46] Functional significance of macrophage-derived exosomes in inflammation and pain [J].

McDonald, Marguerite K. ;

Tian, Yuzhen ;

Qureshi, Rehman A. ;

Gormley, Michael ;

Ertel, Adam ;

Gao, Ruby ;

Lopez, Enrique Aradillas ;

Alexander, Guillermo M. ;

Sacan, Ahmet ;

Fortina, Paolo ;

Ajit, Seena K. .

PAIN, 2014, 155 (08) :1527-1539

[47] KRAS-MEK Signaling Controls Ago2 Sorting into Exosomes [J].

McKenzie, Andrew J. ;

Hoshino, Daisuke ;

Hong, Nan Hyung ;

Cha, Diana J. ;

Franklin, Jeffrey L. ;

Coffey, Robert J. ;

Patton, James G. ;

Weaver, Alissa M. .

CELL REPORTS, 2016, 15 (05) :978-987

[48] Cancer Exosomes Perform Cell-Independent MicroRNA Biogenesis and Promote Tumorigenesis [J].

Melo, Sonia A. ;

Sugimoto, Hikaru ;

O'Connell, Joyce T. ;

Kato, Noritoshi ;

Villanueva, Alberto ;

Vidal, August ;

Qiu, Le ;

Vitkin, Edward ;

Perelman, Lev T. ;

Melo, Carlos A. ;

Lucci, Anthony ;

Ivan, Cristina ;

Calin, George A. ;

Kalluri, Raghu .

CANCER CELL, 2014, 26 (05) :707-721

[49] Diagnostic and prognostic relevance of circulating exosomal miR-373, miR-200a, miR-200b and miR-200c in patients with epithelial ovarian cancer [J].

Meng, Xiaodan ;

Mueller, Volkmar ;

Milde-Langosch, Karin ;

Trillsch, Fabian ;

Pantel, Klaus ;

Schwarzenbach, Heidi .

ONCOTARGET, 2016, 7 (13) :16923-16935

[50] Large oncosomes contain distinct protein cargo and represent a separate functional class of tumor-derived extracellular vesicles [J].

Minciacchi, Valentina R. ;

You, Sungyong ;

Spinelli, Cristiana ;

Morley, Samantha ;

Zandian, Mandana ;

Aspuria, Paul-Joseph ;

Cavallini, Lorenzo ;

Ciardiello, Chiara ;

Sobreiro, Mariana Reis ;

Morello, Matteo ;

Kharmate, Geetanjali ;

Jang, Su Chul ;

Kim, Dae-Kyum ;

Hosseini-Beheshti, Elham ;

Guns, Emma Tomlinson ;

Gleave, Martin ;

Gho, Yong Song ;

Mathivanan, Suresh ;

Yang, Wei ;

Freeman, Michael R. ;

Di Vizio, Dolores .

ONCOTARGET, 2015, 6 (13) :11327-11341

← 1 2 3 4 5 6 7 8 9 →