D-dimer testing in clinical practice in the era of COVID-19

被引：14

作者：

Auditeau, Claire ^{[1
]}

Khider, Lina ^{[2
,3
,4
]}

Planquette, Benjamin ^{[2
,3
,5
,6
]}

Sanchez, Olivier ^{[2
,3
,5
,6
]}

Smadja, David M. ^{[1
,2
,3
,6
]}

Gendron, Nicolas ^{[1
,2
,3
]}

机构：

[1] Ctr Univ Paris APHP CUP, AP HP, Hematol Dept, Paris, France

[2] Univ Paris Cite, INSERM, Innovat Therapies Haemostasis, Paris, France

[3] Ctr Univ Paris APHP CUP, AP HP, Carpentier Fdn, Biosurg Res Lab, Paris, France

[4] Ctr Univ Paris APHP CUP, AP HP, Vasc Med Dept, Paris, France

[5] Ctr Univ Paris APHP CUP, AP HP, Resp Med Dept, Paris, France

[6] F CRIN INNOVTE, St Etienne, France

来源：

RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS | 2022年 / 6卷 / 04期

关键词：

anticoagulant; biomarker; COVID-19; vaccines; D-dimer; disseminated intravascular coagulation; fibrin; fibrin fragment D; fibrinogen degradation products; predictive value of tests; prognosis; pulmonary embolism; venous thromboembolism; PULMONARY-EMBOLISM; ALGORITHM;

D O I：

10.1002/rth2.12730

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

D-dimer is a fragment of crosslinked fibrin resulting from plasmin cleavage of fibrin clots and hence an indirect biomarker of the hemostatic system activation. Early in the coronavirus disease 2019 (COVID-19) pandemic, several studies described coagulation disorders in affected patients, including high D-dimer levels. Consequently, D-dimer has been widely used in not-yet-approved indications. Ruling out pulmonary embolism and deep vein thrombosis in patients with low or intermediate clinical suspicion is the main application of D-dimer. D-dimer is also used to estimate the risk of venous thromboembolism recurrence and is included in the ISTH algorithm for the diagnosis of disseminated intravascular coagulation. Finally, numerous studies identified high D-dimer levels as a biomarker of poor prognosis in hospitalized patients with COVID-19. This report focuses on validated applications of D-dimer testing in patients with and without COVID-19.

引用

页数：5

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