Methuselah/Methuselah-like G protein-coupled receptors constitute an ancient metazoan gene family

被引：23
作者：
de Mendoza, Alexandre [1 ]
Jones, Jeffery W. [2 ,4 ]
Friedrich, Markus [2 ,3 ]
机构：
[1] Univ Western Australia, Sch Chem & Biochem, Ctr Excellence, Plant Energy Biol Australian Res Council, Perth, WA 6009, Australia
[2] Wayne State Univ, Dept Biol Sci, 5047 Gullen Mall, Detroit, MI 48202 USA
[3] Wayne State Univ, Sch Med, Dept Anat & Cell Biol, 540 East Canfield Ave, Detroit, MI 48201 USA
[4] Advaxis Inc, 305 Coll Rd East, Princeton, NJ 08540 USA
来源：
SCIENTIFIC REPORTS | 2016年 / 6卷
关键词：
LIFE-SPAN; STRESS RESISTANCE; METHUSELAH; DROSOPHILA; REPERTOIRE; EVOLUTION;
D O I：
10.1038/srep21801
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Inconsistent conclusions have been drawn regarding the phylogenetic age of the Methuselah/Methuselah-like (Mth/Mthl) gene family of G protein-coupled receptors, the founding member of which regulates development and lifespan in Drosophila. Here we report the results from a targeted homolog search of 39 holozoan genomes and phylogenetic analysis of the conserved seven transmembrane domain. Our findings reveal that the Mth/Mthl gene family is ancient, has experienced numerous extinction and expansion events during metazoan evolution, and acquired the current definition of the Methuselah ectodomain during its exceptional expansion in arthropods. In addition, our findings identify Mthl1, Mthl5, Mthl14, and Mthl15 as the oldest Mth/Mthl gene family paralogs in Drosophila. Future studies of these genes have the potential to define ancestral functions of the Mth/Mthl gene family.
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页数：5
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