The anorectic effect of neurotensin is mediated via a histamine H1 receptor in mice

Neurotensin (NT), a tridecapeptide found in the mammalian brain and peripheral tissues. induces a decrease in food intake after central administration. In this investiaation, we examine whether the histaminergic system is involved in NIT-induced suppression of feeding. Intracerebroventricular injection of NT (0. 1 -1 nmol/mouse) led to dose-dependent inhibition of food intake in fasted ddY mice. The anorectic effect induced by NT (0.1 nmol/mouse) was ameliorated upon co-administration of pyrilamine (3 nmol/mouse). an antagonist for histomine H, receptor. The NT-induced anorectic effect was partially ameliorated in H, knockout mice. The findings suggest that the H, receptor in pan mediates the NT-induced suppression of food intake. (C) 2004 Elsevier Inc. All rights reserved.