The anorectic effect of neurotensin is mediated via a histamine H1 receptor in mice

被引：16

作者：

Ohinata, K

Shimano, T

Yamauchi, R

Sakurada, S

Yanai, K

Yoshikawa, M ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Agr, Div Food Sci & Biotechnol, Uji, Kyoto 6110011, Japan

[2] Tohoku Pharmaceut Univ, Dept Physiol & Anat, Aoba Ku, Sendai, Miyagi 9818558, Japan

[3] Tohoku Univ, Sch Med, Dept Pharmacol, Aoba Ku, Sendai, Miyagi 9808575, Japan

来源：

PEPTIDES | 2004年 / 25卷 / 12期

关键词：

neurotensin; histamine; H-1; receptor; food intakes; leptin;

D O I：

10.1016/j.peptides.2004.07.009

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Neurotensin (NT), a tridecapeptide found in the mammalian brain and peripheral tissues. induces a decrease in food intake after central administration. In this investiaation, we examine whether the histaminergic system is involved in NIT-induced suppression of feeding. Intracerebroventricular injection of NT (0. 1 -1 nmol/mouse) led to dose-dependent inhibition of food intake in fasted ddY mice. The anorectic effect induced by NT (0.1 nmol/mouse) was ameliorated upon co-administration of pyrilamine (3 nmol/mouse). an antagonist for histomine H, receptor. The NT-induced anorectic effect was partially ameliorated in H, knockout mice. The findings suggest that the H, receptor in pan mediates the NT-induced suppression of food intake. (C) 2004 Elsevier Inc. All rights reserved.

引用

页码：2135 / 2138

页数：4

共 25 条

[1] Ghrelin is an appetite-stimulatory signal from stomach with structural resemblance to motilin [J].