Anthraquinones from the Aerial Parts of Rubia cordifolia with Their NO Inhibitory and Antibacterial Activities

被引：11

作者：

Luo, Han ^{[1
]}

Qin, Wei ^{[1
]}

Zhang, Hong ^{[1
]}

Ren, Fu-Cai ^{[2
,3
]}

Fang, Wen-Tao ^{[1
]}

Kong, Qing-Hua ^{[2
]}

Yang, Liu ^{[2
]}

Zhang, Jian-Mei ^{[2
]}

Fang, Cheng-Wu ^{[1
]}

Hu, Jiang-Miao ^{[2
]}

Liu, Shou-Jin ^{[1
]}

机构：

[1] Anhui Univ Chinese Med, Coll Pharm, Hefei 230011, Peoples R China

[2] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China

[3] Anhui Med Univ, Coll Pharm, Hefei 230011, Peoples R China

来源：

MOLECULES | 2022年 / 27卷 / 05期

关键词：

Rubia cordifolia; anthraquinones; NO inhibitory activity; antibacterial; NITRIC-OXIDE; MEDICINAL-PLANT; CELL-CULTURES; L-ARGININE; CONSTITUENTS; BIOSYNTHESIS; DERIVATIVES; MECHANISMS; DISEASE;

D O I：

10.3390/molecules27051730

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The present study aimed to identify the composition of the aerial parts of Rubia cordifolia L. A chemical investigation on the EtOAc extracts from the aerial parts of Rubia cordifolia resulted in the isolation of four new anthraquinones, namely Cordifoquinone A-D (1-4), along with 16 known anthraquinones. Their structures were elucidated on the basis of NMR and HR-ESIMS data. All isolates were assessed for their inhibitory effects on NO production in LPS-stimulated RAW264.7 macrophage cells. Compounds 1, 3 and 10 exhibited significant inhibitory activities with IC50 values of 14.05, 23.48 and 29.23 mu mol.L-1, respectively. Their antibacterial activities of four bacteria, Escherichia coli (ATCC 25922), Staphylococcus aureus subsp. aureus (ATCC 29213), Salmonella enterica subsp. enterica (ATCC 14028) and Pseudomonas aeruginosa (ATCC 27853), were also evaluated. Our results indicated that the antibacterial activity of these compounds is inactive.

引用

页数：12

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