Characterization of site-specific glycosylation of secreted proteins associated with multi-drug resistance of gastric cancer

被引：34

作者：

Wu, Jian ^{[1
,2
]}

Qin, Hongqiang ^{[3
]}

Li, Ting ^{[1
,2
]}

Cheng, Kai ^{[3
]}

Dong, Jiaqiang ^{[1
,2
]}

Tian, Miaomiao ^{[1
,2
]}

Chai, Na ^{[1
,2
]}

Guo, Hao ^{[1
,2
]}

Li, Jinjing ^{[1
,2
]}

You, Xin ^{[3
]}

Dong, Mingming ^{[3
]}

Ye, Mingliang ^{[3
]}

Nie, Yongzhan ^{[1
,2
]}

Zou, Hanfa ^{[3
]}

Fan, Daiming ^{[1
,2
]}

机构：

[1] Fourth Mil Med Univ, State Key Lab Canc Biol, Xian 710032, Peoples R China

[2] Fourth Mil Med Univ, Xijing Hosp Digest Dis, Xian 710032, Peoples R China

[3] Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Natl Chromatog R&A Ctr, Dalian 116023, Peoples R China

来源：

ONCOTARGET | 2016年 / 7卷 / 18期

关键词：

gastric cancer; secretome analysis; chemoresistance; glycoprotein; site-specific glycosylation; RECEPTOR TYROSINE KINASE; MEDIATES RESISTANCE; CELL-PROLIFERATION; TISSUE INHIBITOR; DRUG-RESISTANCE; AXL; TUMOR; CLUSTERIN; ACTIVATION; CARCINOMA;

D O I：

10.18632/oncotarget.8287

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Multi-drug resistance (MDR) remains a great obstacle to effective chemotherapy for gastric cancer. A number of secreted glycoproteins have been reported to be involved in the development of MDR in gastric cancer. However, whether glycosylation of secreted glycoproteins changes during MDR of gastric cancer is unclear. Our present work manifested that N-glycosites and site-specific glycoforms of secreted proteins in drug-resistant cell lines were distinctly different from those in the parental cell line for the first time. Further characterization highlighted the significance of some aberrantly glycosylated secretory proteins in MDR, suggesting that manipulating the glycosylation of specific glycoproteins could be a potential target for overcoming multi-drug resistance in gastric cancer.

引用

页码：25315 / 25327

页数：13

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