Fetal cells in mother rats contribute to the remodeling of liver and kidney after injury

被引：102

作者：

Wang, Y ^{[1
]}

Iwatani, H ^{[1
]}

Ito, T ^{[1
]}

Horimoto, N ^{[1
]}

Yamato, M ^{[1
]}

Matsui, I ^{[1
]}

Imai, E ^{[1
]}

Hori, M ^{[1
]}

机构：

[1] Osaka Univ, Sch Med, Dept Internal Med & Therapeut, Suita, Osaka 565, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2004年 / 325卷 / 03期

关键词：

fetal cells; microchimerism; injury; green fluorescent protein;

D O I：

10.1016/j.bbrc.2004.10.105

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Fetal microchimerism indicates a mixture of cells of maternal and fetal origin seen in maternal tissues during and after pregnancy. Controversy exists about whether persistent fetal microchimerism is related with some autoimmune disorders occurring during and after pregnancy. In the current experiment, an animal model in which EGFP positive cells were taken as fetal-origin cells was designed to detect the fetal microchimerism in various maternal organs. Ethanol drinking and gentamicin injection were adopted to induce liver and kidney injury simultaneously. EGFP positive cells were engrafted not only in the maternal circulation and bone marrow, but also in the liver and kidney as hepatocytes and tubular cells, respectively. These results indicate that fetal cells are engrafted to maternal hematopoietic system without apparent injury and they also contribute to the repairing process of maternal liver and kidney. (C) 2004 Elsevier Inc. All rights reserved.

引用

页码：961 / 967

页数：7

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