Dynamics of the membrane-cytoskeleton interface in MHC class II-restricted antigen presentation

被引：14
|
作者：
Bretou, Marine [1 ,2 ]
Kumari, Anita [1 ,2 ]
Malbec, Odile [1 ,2 ]
Moreau, Helene D. [1 ,2 ]
Obino, Dorian [1 ,2 ]
Pierobon, Paolo [1 ,2 ]
Randrian, Violaine [1 ,2 ]
Saez, Pablo J. [1 ,2 ]
Lennon-Dumenil, Ana-Maria [1 ,2 ]
机构：
[1] Inst Curie, INSERM, U932, ANR IDEX PSL 10 0001 02, 12 Rue Lhomond, F-75005 Paris, France
[2] ANR 11 LABX 0043, 12 Rue Lhomond, F-75005 Paris, France
来源：
IMMUNOLOGICAL REVIEWS | 2016年 / 272卷 / 01期
基金：
欧洲研究理事会;
关键词：
dendritic cell; B lymphocyte; antigen presentation; cytoskeleton; cell polarity; membrane trafficking; B-CELL RECEPTOR; EXOGENOUS SOLUBLE-ANTIGEN; HLA-DR MOLECULES; FC-GAMMA-R; DENDRITIC CELLS; INVARIANT CHAIN; MYOSIN-II; CONSTITUTIVE MACROPINOCYTOSIS; ACTIN CYTOSKELETON; CATHEPSIN-S;
D O I：
10.1111/imr.12429
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Antigen presentation refers to the ability of cells to show MHC-associated determinants to T lymphocytes, leading to their activation. MHC class II molecules mainly present peptide-derived antigens that are internalized by endocytosis in antigen-presenting cells (APCs). Here, we describe how the interface between cellular membranes and the cytoskeleton regulates the various steps that lead to the presentation of exogenous antigens on MHC class II molecules in the two main types of APCs: dendritic cells (DCs) and B lymphocytes. This includes antigen uptake, processing, APC migration, and APC-T cell interactions. We further discuss how the interaction between APC-specific molecules and cytoskeleton elements allows the coordination of antigen presentation and cell migration in time and space.
引用
收藏
页码：39 / 51
页数：13
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