Circadian disruption induced by light-at-night accelerates aging and promotes tumorigenesis in rats

被引：71

作者：

Vinogradova, Irina A. ^{[2
]}

Anisimov, Vladimir N. ^{[1
]}

Bukalev, Andrey V. ^{[2
]}

Semenchenko, Anna V. ^{[1
]}

Zabezhinski, Mark A. ^{[1
]}

机构：

[1] NN Petrov Oncol Res Inst, Dept Carcinogenesis & Oncogerontol, St Petersburg 197748, Russia

[2] Petrozavodsk State Univ, Petrozavodsk 185910, Russia

来源：

AGING-US | 2009年 / 1卷 / 10期

基金：

俄罗斯基础研究基金会;

关键词：

light-at-night; life span; tumorigenesis; rats; CANCER INCIDENCE; BREAST-CANCER; SHIFT-WORK; LIFE-SPAN; INSULIN-SECRETION; HEART-DISEASE; MELATONIN; RISK; SAMI; MICE;

D O I：

10.18632/aging.100092

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

We evaluated the effect of various light/dark regimens on the survival, life span and tumorigenesis in rats. Two hundred eight male and 203 females LIO rats were subdivided into 4 groups and kept at various light/dark regimens: standard 12:12 light/dark (LD); natural lighting of the North-West of Russia (NL); constant light (LL), and constant darkness (DD) since the age of 25 days until natural death. We found that exposure to NL and LL regimens accelerated development of metabolic syndrome and spontaneous tumorigenesis, shortened life span both in male and females rats as compared to the standard LD regimen. We conclude that circadian disruption induced by light-at-night accelerates aging and promotes tumorigenesis in rats. This observation supports the conclusion of the International Agency Research on Cancer that shift work that involves circadian disruption is probably carcinogenic to humans.

引用

页码：855 / 865

页数：11

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