Intestinal alkaline phosphatase: a summary of its role in clinical disease

被引：136
作者：
Fawley, Jason [1 ,2 ]
Gourlay, David M. [1 ,2 ]
机构：
[1] Med Coll Wisconsin, Dept Surg, Div Pediat Surg, 8700 W Wisconsin Ave, Milwaukee, WI 53226 USA
[2] Childrens Hosp Wisconsin, Div Pediat Surg, Dept Surg, Milwaukee, WI 53201 USA
来源：
JOURNAL OF SURGICAL RESEARCH | 2016年 / 202卷 / 01期
关键词：
IAP; Sepsis; NEC; IBD; Metabolic syndrome; Intestinal microbiome; Bacterial translocation; NECROTIZING ENTEROCOLITIS; METABOLIC SYNDROME; ENTEROCYTE MICROVILLUS; COLONIC-MUCOSA; GUT BARRIER; SEPSIS; INFLAMMATION; PATHOGENESIS; MICROBIOTA; EXPRESSION;
D O I：
10.1016/j.jss.2015.12.008
中图分类号：
R61 [外科手术学];
学科分类号：
摘要：
Over the past few years, there is increasing evidence implicating a novel role for Intestinal Alkaline Phosphatase (IAP) in mitigating inflammatory mediated disorders. IAP is an endogenous protein expressed by the intestinal epithelium that is believed to play a vital role in maintaining gut homeostasis. Loss of IAP expression or function is associated with increased intestinal inflammation, dysbiosis, bacterial translocation and subsequently systemic inflammation. As these events are a cornerstone of the pathophysiology of many diseases relevant to surgeons, we sought to review recent research in both animal and humans on IAP's physiologic function, mechanisms of action and current research in specific surgical diseases. (C) 2016 Elsevier Inc. All rights reserved.
引用
收藏
页码：225 / 234
页数：10
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  • [1] Intestinal Alkaline Phosphatase Prevents Antibiotic-Induced Susceptibility to Enteric Pathogens
    Alam, Sayeda Nasrin
    Yammine, Halim
    Moaven, Omeed
    Ahmed, Rizwan
    Moss, Angela K.
    Biswas, Brishti
    Muhammad, Nur
    Biswas, Rakesh
    Raychowdhury, Atri
    Kaliannan, Kanakaraju
    Ghosh, Sathi
    Ray, Madhury
    Hamarneh, Sulaiman R.
    Barua, Soumik
    Malo, Nondita S.
    Bhan, Atul K.
    Malo, Madhu S.
    Hodin, Richard A.
    [J]. ANNALS OF SURGERY, 2014, 259 (04) : 715 - 722
  • [2] Intestinal alkaline phosphatase detoxifies lipopolysaccharide and prevents inflammation in zebrafish in response to the gut microbiota
    Bates, Jennifer M.
    Akerlund, Janie
    Mittge, Erika
    Guillemin, Karen
    [J]. CELL HOST & MICROBE, 2007, 2 (06) : 371 - 382
  • [3] Distinct signals from the microbiota promote different aspects of zebrafish gut differentiation
    Bates, Jennifer M.
    Mittge, Erika
    Kuhlman, Julie
    Baden, Katrina N.
    Cheesman, Sarah E.
    Guillemin, Karen
    [J]. DEVELOPMENTAL BIOLOGY, 2006, 297 (02) : 374 - 386
  • [4] Removal of phosphate from lipid a as a strategy to detoxify lipopolysaccharide
    Bentala, H
    Verweij, WR
    Huizinga-Van der Vlag, A
    van Loenen-Weemaes, AM
    Meijer, DKF
    Poelstra, K
    [J]. SHOCK, 2002, 18 (06): : 561 - 566
  • [5] Calf intestinal alkaline phosphatase, a novel therapeutic drug for lipopolysaccharide (LPS)-mediated diseases, attenuates LPS toxicity in mice and piglets
    Beumer, C
    Wulferink, M
    Raaben, W
    Fiechter, D
    Brands, R
    Seinen, W
    [J]. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2003, 307 (02) : 737 - 744
  • [6] The immunological and genetic basis of inflammatory bowel disease
    Bouma, G
    Strober, W
    [J]. NATURE REVIEWS IMMUNOLOGY, 2003, 3 (07) : 521 - 533
  • [7] Metabolic endotoxemia initiates obesity and insulin resistance
    Cani, Patrice D.
    Amar, Jacques
    Iglesias, Miguel Angel
    Poggi, Marjorie
    Knauf, Claude
    Bastelica, Delphine
    Neyrinck, Audrey M.
    Fava, Francesca
    Tuohy, Kieran M.
    Chabo, Chantal
    Waget, Aurelie
    Delmee, Evelyne
    Cousin, Beatrice
    Sulpice, Thierry
    Chamontin, Bernard
    Ferrieres, Jean
    Tanti, Jean-Francois
    Gibson, Glenn R.
    Casteilla, Louis
    Delzenne, Nathalie M.
    Alessi, Marie Christine
    Burcelin, Remy
    [J]. DIABETES, 2007, 56 (07) : 1761 - 1772
  • [8] Differential alteration in intestinal epithelial cell expression of Toll-like receptor 3 (TLR3) and TLR4 in inflammatory bowel disease
    Cario, E
    Podolsky, DK
    [J]. INFECTION AND IMMUNITY, 2000, 68 (12) : 7010 - 7017
  • [9] Identification of specific targets for the gut mucosal defense factor intestinal alkaline phosphatase
    Chen, Kathryn T.
    Malo, Madhu S.
    Moss, Angela K.
    Zeller, Skye
    Johnson, Paul
    Ebrahimi, Farzad
    Mostafa, Golam
    Alam, Sayeda N.
    Ramasamy, Sundaram
    Warren, H. Shaw
    Hohmann, Elizabeth L.
    Hodin, Richard A.
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2010, 299 (02): : G467 - G475
  • [10] A Mouse Model of Clostridium difficile-Associated Disease
    Chen, Xinhua
    Katchar, Kianoosh
    Goldsmith, Jeffrey D.
    Nanthakumar, Nanda
    Cheknis, Adam
    Gerding, Dale N.
    Kelly, Ciaran P.
    [J]. GASTROENTEROLOGY, 2008, 135 (06) : 1984 - 1992
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