Silver(I)-Mediated Phosphorylation/Cyclization Cascade of N-Cyanamide Alkenes for Divergent Access to Quinazolinones and Dihydroisoquinolinones

被引：110

作者：

Zheng, Jing ^{[1
]}

Zhang, Yan ^{[1
]}

Wang, Dahai ^{[1
]}

Cui, Sunliang ^{[1
]}

机构：

[1] Zhejiang Univ, Coll Pharmaceut Sci, Inst Drug Discovery & Design, 866 Yuhangtang Rd, Hangzhou 310058, Zhejiang, Peoples R China

来源：

ORGANIC LETTERS | 2016年 / 18卷 / 08期

基金：

中国国家自然科学基金;

关键词：

OXIDATIVE CYCLIZATION; RADICAL CYCLIZATION; FACILE SYNTHESIS; C-C; FUNCTIONALIZATION; BENZAMIDES; INDOLES; OXIDES;

D O I：

10.1021/acs.orglett.6b00481

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A silver(I)-mediated phosphorylation/cyclization radical cascade of N-cyanamide alkenes has been developed. The addition of in situ generated phosphorus radical to N-cyanamide alkenes triggers the cascade, resulting in late-stage cyclization toward divergent access to 4-quinazolinones and dihydroisoquinolinones. Both terminal and internal N-cyanamide alkenes are applicable in this protocol, and the cyclizations are consistent with Baldwin's rule.

引用

页码：1768 / 1771

页数：4

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