Early pregnancy sex steroids during primiparous pregnancies and maternal breast cancer: a nested case-control study in the Northern Sweden Maternity Cohort

被引:8
作者
Fortner, Renee T. [1 ]
Tolockiene, Egle [2 ]
Schock, Helena [1 ]
Oda, Husam [2 ]
Lakso, Hans Ake [3 ]
Hallmans, Goeran [4 ]
Kaaks, Rudolf [1 ]
Toniolo, Paolo [5 ]
Zeleniuch-Jacquotte, Anne [6 ,7 ]
Grankvist, Kjell [3 ]
Lundin, Eva [2 ]
机构
[1] German Canc Res Ctr, Div Canc Epidemiol, Neuenheimer Feld 280, D-69120 Heidelberg, Germany
[2] Umea Univ, Dept Med Biosci, Pathol, Umea, Sweden
[3] Umea Univ, Dept Med Biosci, Clin Chem, Umea, Sweden
[4] Umea Univ, Publ Hlth & Clin Med Nutr Res, Umea, Sweden
[5] NYU, Sch Med, Dept Obstet & Gynecol, New York, NY USA
[6] NYU, Sch Med, Dept Populat Hlth, New York, NY USA
[7] NYU, Sch Med, Perlmutter Canc Ctr, New York, NY USA
来源
BREAST CANCER RESEARCH | 2017年 / 19卷
基金
美国国家卫生研究院;
关键词
Endogenous hormones; Early pregnancy; Breast cancer; Sex steroids; HORMONE LEVELS; RISK; PROGESTERONE; RECEPTOR;
D O I
10.1186/s13058-017-0876-8
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background: Pregnancy and parity are associated with subsequent breast cancer risk. Experimental and epidemiologic data suggest a role for pregnancy sex steroid hormones. Methods: We conducted a nested case-control study in the Northern Sweden Maternity Cohort (1975-2007). Eligible women had provided a blood sample in the first 20 weeks of gestation during a primiparous pregnancy leading to a term delivery. The current study includes 223 cases and 417 matched controls (matching factors: age at and date of blood collection). Estrogen receptor (ER) and progesterone receptor (PR) status was available for all cases; androgen receptor (AR) data were available for 41% of cases (n = 92). Sex steroids were quantified by high-performance liquid chromatography tandem mass spectrometry. Odds ratios (ORs) and 95% confidence intervals were estimated using conditional logistic regression. Results: Higher concentrations of circulating progesterone in early pregnancy were inversely associated with ER+/PR+ breast cancer risk (ORlog2: 0.64 (0.41-1.00)). Higher testosterone was positively associated with ER+/PR+ disease risk (ORlog2: 1.57 (1.13-2.18)). Early pregnancy estrogens were not associated with risk, except for relatively high estradiol in the context of low progesterone (split at median, relative to low concentrations of both; OR: 1.87 (1.11-3.16)). None of the investigated hormones were associated with ER-/PR-disease, or with AR+ or AR+/ER+/PR+ disease. Conclusions: Consistent with experimental models, high progesterone in early pregnancy was associated with lower risk of ER+/PR+ breast cancer in the mother. High circulating testosterone in early pregnancy, which likely reflects nonpregnant premenopausal exposure, was associated with higher risk of ER+/PR+ disease.
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页数:8
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