MALAT1 induced migration and invasion of human breast cancer cells by competitively binding miR-1 with cdc42

被引：173
作者：
Chou, Jinjiang [1 ,2 ]
Wang, Bingyu [1 ,2 ]
Zheng, Tianjing [1 ,2 ]
Li, Xiaoman [2 ,3 ]
Zheng, Lufeng [1 ,2 ]
Hu, Jinhang [1 ,2 ]
Zhang, Yan [1 ,2 ]
Xing, Yingying [1 ,2 ]
Xi, Tao [1 ,2 ]
机构：
[1] China Pharmaceut Univ, Sch Life Sci & Technol, 24 Tongjiaxiang, Nanjing 210009, Peoples R China
[2] China Pharmaceut Univ, Jiangsu Key Lab Carcinogenesis & Intervent, 24 Tongjiaxiang, Nanjing 210009, Peoples R China
[3] Nanjing Univ Chinese Med, Jingsu Key Lab Pharmacol & Safety Evaluat Chinese, Sch Pharm, Nanjing 210023, Jiangsu, Peoples R China
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2016年 / 472卷 / 01期
关键词：
MALAT1; miR-1; cdc42; ceRNA; Migration; Invasion; NONCODING RNA MALAT1; METASTASIS; EXPRESSION; PROMOTES; PROLIFERATION; ALPHA;
D O I：
10.1016/j.bbrc.2016.02.102
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Competitive endogenous messenger RNAs (ceRNAs) affect other RNAs transcription through competitively binding common microRNAs (miRNAs). In this study we identified long non-coding RNA (lncRNA) MALAT1 can function as a ceRNA of cell division cycle 42 (cdc42) 3'UTR in inducing migration and invasion of breast cancer cells via miR-1. We found that miR-1 bound both MALAT1 and cdc42 3'UTR directly. Further study showed that MALAT1 induced migration and invasion of breast cancer cells while reduced the level of cdc42. Our results suggest that MALAT1 regulated migration and invasion of breast cancer cells via affecting cdc42 through binding miR-1 competitively. (C) 2016 Elsevier Inc. All rights reserved.
引用
收藏
页码：262 / 269
页数：8
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