The Mycobacterium tuberculosis Rv1099c gene encodes a GlpX-like class II fructose 1,6-bisphosphatase

被引：25

作者：

Movahedzadeh, F

Rison, SCG

Wheeler, PR

Kendall, SL

Larson, TJ

Stoker, NG

机构：

[1] Univ London Royal Vet Coll, Dept Pathol & Infect Dis, London NW1 0TU, England

[2] Vet Labs Agcy, TB Res, Addlestone KT15 3NB, Surrey, England

[3] Virginia Polytech Inst & State Univ, Blacksburg, VA 24061 USA

来源：

MICROBIOLOGY-SGM | 2004年 / 150卷

关键词：

D O I：

10.1099/mic.0.27204-0

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

There are now abundant data indicating that Mycobacterium tuberculosis uses fatty acids as a carbon source in vivo. A key enzyme in gluconeogenesis, missing in the original annotation of the M. tuberculosis genome, is fructose 1,6-bisphosphatase (FBPase; EC 3.1.3.11). The authors have shown that M. tuberculosis Rv1099c, a g/pX homologue, can complement Escherichia coli mutants lacking FBPase. The protein encoded by Rv1099c was shown to have FBPase activity. Rv1099c was expressed at significant levels in M. tuberculosis, and may encode the major FBPase of this pathogen.

引用

页码：3499 / 3505

页数：7

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