MicroRNAs: New regulators of IL-22

被引：9

作者：

Lu, Zhou ^{[1
]}

Liu, Ronghua ^{[1
]}

Huang, Enyu ^{[1
]}

Chu, Yiwei ^{[1
,2
]}

机构：

[1] Fudan Univ, Dept Immunol, Sch Basic Med Sci, Shanghai 200032, Peoples R China

[2] Fudan Univ, Biotherapy Res Ctr, Shanghai 200032, Peoples R China

来源：

CELLULAR IMMUNOLOGY | 2016年 / 304卷

基金：

中国博士后科学基金; 中国国家自然科学基金;

关键词：

MicroRNAs; IL-22; Regulators; CD4(+) T-CELLS; ARYL-HYDROCARBON RECEPTOR; INNATE LYMPHOID-CELLS; IL-10; PRODUCTION; INTERLEUKIN; 22; GENE-EXPRESSION; C-MAF; TH17; ACTIVATION; DRIVES;

D O I：

10.1016/j.cellimm.2016.05.003

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Interleukin-22 (IL-22) is a cytokine that belongs to the IL-10 family of interleukins. It can be produced by T helper 22 (Th22) cells, T helper 1 (Th1) cells, T helper 17 (Th17) cells, natural killer 22 (NK22) cells, natural killer T (NKT) cells, innate lymphoid cells (ILCs), and gamma delta T cells. IL-22 acts via binding to a heterodimeric transmembrane receptor complex that consists of IL-22R1 and IL-10R2 and mainly contributes to the tissue repair and host defense. Transcription factors such as retinoid orphan receptor gamma delta (ROR gamma t) and signal transducer and activator of transcription 3 (STAT3), have been reported to play important roles in regulation of IL-22 expression. Recently, it has been demonstrated in several studies that microRNAs (miRNAs) potently regulate expression of interleukins, including production of IL-22. Here, we review current knowledge about regulators of IL-22 expression with a particular emphasis on the role of miRNAs. (C) 2016 Elsevier Inc. All rights reserved.

引用

页码：1 / 8

页数：8

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