Synthesis, analgesic and anti-inflammatory activities of some novel pyrazolines derivatives

被引：86

作者：

Joshi, Ratnadeep S. ^{[1
]}

Mandhane, Priyanka G. ^{[1
]}

Diwakar, Santosh D. ^{[1
]}

Dabhade, Sanjay K. ^{[1
]}

Gill, Charansingh H. ^{[1
]}

机构：

[1] Dr Babasaheb Ambedkar Marathwada Univ, Dept Chem, Aurangabad 431004, Maharashtra, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2010年 / 20卷 / 12期

关键词：

Analgesic; Anti-inflammatory activity; Pyrazolines; N-phenylpyrazol-1-carbothioamide; PHARMACOLOGICAL EVALUATION; RECEPTOR ANTAGONISTS; MONOAMINE-OXIDASE; INHIBITORS; ACID;

D O I：

10.1016/j.bmcl.2010.04.082

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In search for a new analgesic and anti-inflammatory agent with improved potency, we designed and synthesized a series of 3,2-(4,5-dihydro-5-(4-morphilinophenyl)-1H-pyarazol-3-yl) phenols 6(a-g) and its N-phenylpyrazol-1-carbothioamide 7(a-g) by Claisan-Schmidt condensation followed by the reaction of hydrazine hydrate. All the synthesized compounds were assayed for their in vivo analgesic and antiinflammatory activities. All the compounds synthesized showed the potential to demonstrate analgesic and anti-inflammatory activity, of particular interest compounds 6a, 6b, 6g, 7a, 7d and 7g were found comparable to Diclofenac. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：3721 / 3725

页数：5

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