Biomarkers Obtained by Transcranial Magnetic Stimulation in Neurodevelopmental Disorders

被引：10

作者：

Jannati, Ali ^{[1
,2
,3
,4
,5
]}

Ryan, Mary A. ^{[1
,2
,3
,4
]}

Kaye, Harper L. ^{[6
]}

Tsuboyama, Melissa ^{[1
,2
]}

Rotenberg, Alexander ^{[1
,2
,3
,4
,5
]}

机构：

[1] Harvard Med Sch, Boston Childrens Hosp, Dept Neurol, Neuromodulat Program, Boston, MA 02115 USA

[2] Harvard Med Sch, Boston Childrens Hosp, Dept Neurol, Div Epilepsy & Clin Neurophysiol, Boston, MA 02115 USA

[3] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Dept Neurol, Berenson Allen Ctr Noninvas Brain Stimulat, Boston, MA 02115 USA

[4] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Dept Neurol, Div Cognit Neurol, Boston, MA 02115 USA

[5] Harvard Med Sch, Boston Childrens Hosp, Dept Neurol, FM Kirby Neurobiol Ctr, Boston, MA 02115 USA

[6] Boston Univ, Sch Med, Div Med Sci, Behav Neurosci Program, Boston, MA 02118 USA

来源：

JOURNAL OF CLINICAL NEUROPHYSIOLOGY | 2022年 / 39卷 / 02期

基金：

美国国家卫生研究院; 加拿大健康研究院;

关键词：

Transcranial magnetic stimulation; Neurodevelopmental disorders; Pediatrics; Neurology; Biomarkers; THETA-BURST-STIMULATION; DEFICIT HYPERACTIVITY DISORDER; HUMAN MOTOR CORTEX; NONINVASIVE BRAIN-STIMULATION; ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; AUTISM SPECTRUM DISORDERS; CORTICAL SILENT PERIOD; TERM POTENTIATION-LIKE; LA-TOURETTE SYNDROME; FRAGILE-X-SYNDROME;

D O I：

10.1097/WNP.0000000000000784

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Transcranial magnetic stimulation (TMS) is a method for focal brain stimulation that is based on the principle of electromagnetic induction where small intracranial electric currents are generated by a powerful fluctuating magnetic field. Over the past three decades, TMS has shown promise in the diagnosis, monitoring, and treatment of neurological and psychiatric disorders in adults. However, the use of TMS in children has been more limited. We provide a brief introduction to the TMS technique; common TMS protocols including single-pulse TMS, paired-pulse TMS, paired associative stimulation, and repetitive TMS; and relevant TMS-derived neurophysiological measurements including resting and active motor threshold, cortical silent period, paired-pulse TMS measures of intracortical inhibition and facilitation, and plasticity metrics after repetitive TMS. We then discuss the biomarker applications of TMS in a few representative neurodevelopmental disorders including autism spectrum disorder, fragile X syndrome, attention-deficit hyperactivity disorder, Tourette syndrome, and developmental stuttering.

引用

页码：135 / 148

页数：14

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