Regulation of plant innate immunity by three proteins in a complex conserved across the plant and animal kingdoms

被引：133
作者：
Palma, Kristoffer
Zhao, Qingguo
Cheng, Yu Ti
Bi, Dongling
Monaghan, Jacqueline
Cheng, Wei
Zhang, Yuelin
Li, Xin [1 ]
机构：
[1] Univ British Columbia, Michael Smith Labs, Vancouver, BC V6T 1Z4, Canada
[2] Univ British Columbia, Grad Program Genet, Vancouver, BC V6T 1Z3, Canada
[3] Natl Inst Biol Sci, Beijing 102206, Peoples R China
[4] Univ British Columbia, Dept Bot, Vancouver, BC V6T 1Z4, Canada
来源：
GENES & DEVELOPMENT | 2007年 / 21卷 / 12期
关键词：
D O I：
10.1101/gad.1559607
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Innate immunity against pathogen infection is an evolutionarily conserved process among multicellular organisms. Arabidopsis SNC1 encodes a Resistance protein that combines attributes of multiple mammalian pattern recognition receptors. Utilizing snc1 as an autoimmune model, we identified a discrete protein complex containing at least three members-MOS4 ( Modifier Of snc1, 4), AtCDC5, and PRL1 ( Pleiotropic Regulatory Locus 1)-that are all essential for plant innate immunity. AtCDC5 has DNA-binding activity, suggesting that this complex probably regulates defense responses through transcriptional control. Since the complex components along with their interactions are highly conserved from fission yeast to Arabidopsis and human, they may also have a yet-to-be-identified function in mammalian innate immunity.
引用
收藏
页码：1484 / 1493
页数：10
相关论文
共 47 条
[1]   Different requirements for EDS1 and NDR1 by disease resistance genes define at least two R gene-mediated signaling pathways in Arabidopsis [J].
Aarts, N ;
Metz, M ;
Holub, E ;
Staskawicz, BJ ;
Daniels, MJ ;
Parker, JE .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (17) :10306-10311
[2]   Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry [J].
Ajuh, P ;
Kuster, B ;
Panov, K ;
Zomerdijk, JCBM ;
Mann, M ;
Lamond, AI .
EMBO JOURNAL, 2000, 19 (23) :6569-6581
[3]   A direct interaction between the carboxyl-terminal region of CDC5L, and the WD40 domain of PLRG1 is essential for pre-mRNA splicing [J].
Ajuh, P ;
Sleeman, J ;
Chusainow, J ;
Lamond, AI .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (45) :42370-42381
[4]   Pathogen recognition and innate immunity [J].
Akira, S ;
Uematsu, S ;
Takeuchi, O .
CELL, 2006, 124 (04) :783-801
[5]   Regulatory role of SGT1 in early R gene-mediated plant defenses [J].
Austin, MJ ;
Muskett, P ;
Kahn, K ;
Feys, BJ ;
Jones, JDG ;
Parker, JE .
SCIENCE, 2002, 295 (5562) :2077-2080
[6]   Are innate immune signaling pathways in plants and animals conserved? [J].
Ausubel, FM .
NATURE IMMUNOLOGY, 2005, 6 (10) :973-979
[7]   The RAR1 interactor SGT1, an essential component of R gene-triggered disease resistance [J].
Azevedo, C ;
Sadanandom, A ;
Kitagawa, K ;
Freialdenhoven, A ;
Shirasu, K ;
Schulze-Lefert, P .
SCIENCE, 2002, 295 (5562) :2073-2076
[8]   Salicylic acid-independent ENHANCED DISEASE SUSCEPTIBILITY1 signaling in Arabidopsis immunity and cell death is regulated by the monooxygenase FMO1 and the nudix hydrolase NUDT7 [J].
Bartsch, M ;
Gobbato, E ;
Bednarek, P ;
Debey, S ;
Schultze, JL ;
Bautor, J ;
Parker, JE .
PLANT CELL, 2006, 18 (04) :1038-1051
[9]   Plant disease resistance protein signaling: NBS-LRR proteins and their partners [J].
Belkhadir, Y ;
Subramaniam, R ;
Dangl, JL .
CURRENT OPINION IN PLANT BIOLOGY, 2004, 7 (04) :391-399
[10]   Host-microbe interactions: Shaping the evolution of the plant immune response [J].
Chisholm, ST ;
Coaker, G ;
Day, B ;
Staskawicz, BJ .
CELL, 2006, 124 (04) :803-814
12345