Towards Clinically Relevant Oculomotor Biomarkers in Early Schizophrenia

被引：4
作者：
Athanasopoulos, Fotios [1 ,2 ]
Saprikis, Orionas-Vasilis [1 ,2 ]
Margeli, Myrto [1 ,2 ]
Klein, Christoph [1 ,3 ,4 ]
Smyrnis, Nikolaos [1 ,2 ]
机构：
[1] Natl & Kapodistrian Univ Athens, Univ Gen Hosp ATTIKON, Sch Med, Dept Psychiat 2, Athens, Greece
[2] Univ Mental Hlth, Neurosci & Precis Med Res Inst COSTAS STEFANIS, Lab Cognit Neurosci & Sensorimotor Control, Athens, Greece
[3] Univ Freiburg, Med Fac, Dept Child & Adolescent Psychiat, Freiburg, Germany
[4] Univ Cologne, Med Fac, Dept Child & Adolescent Psychiat, Cologne, Germany
来源：
FRONTIERS IN BEHAVIORAL NEUROSCIENCE | 2021年 / 15卷
关键词：
oculomotor; biomarker; schizophrenia; first episode psychosis; recent onset; ultra-high risk; EXPLORATORY EYE-MOVEMENTS; ANTISACCADE TASK-PERFORMANCE; WORKING-MEMORY TASK; HIGH-RISK STATE; SMOOTH-PURSUIT; TRACKING DYSFUNCTION; INTERMEDIATE PHENOTYPE; 1ST-DEGREE RELATIVES; TEMPORAL STABILITY; AFFECTIVE-DISORDER;
D O I：
10.3389/fnbeh.2021.688683
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
In recent years, psychiatric research has focused on the evaluation and implementation of biomarkers in the clinical praxis. Oculomotor function deviances are among the most consistent and replicable cognitive deficits in schizophrenia and have been suggested as viable candidates for biomarkers. In this narrative review, we focus on oculomotor function in first-episode psychosis, recent onset schizophrenia as well as individuals at high risk for developing psychosis. We critically discuss the evidence for the possible utilization of oculomotor function measures as diagnostic, susceptibility, predictive, monitoring, and prognostic biomarkers for these conditions. Based on the current state of research we conclude that there are not sufficient data to unequivocally support the use of oculomotor function measures as biomarkers in schizophrenia.
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页数：9
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