The association of triglyceride and glucose index, and triglyceride to high-density lipoprotein cholesterol ratio with prehypertension and hypertension in normoglycemic subjects: A large cross-sectional population study

被引:41
作者
Zhang, Fomin [1 ]
Zhang, Yingyi [2 ]
Guo, Zhigang [2 ]
Yang, Hua [2 ]
Ren, Min [3 ]
Xing, Xiaomeng [1 ]
Cong, Hongliang [2 ]
机构
[1] Tianjin Med Univ, Tianjin, Peoples R China
[2] Tianjin Chest Hosp, 261 Taierzhuang South Rd, Tianjin 300222, Peoples R China
[3] Tianjin Cardiovasc Inst, Tianjin, Peoples R China
关键词
hypertension; insulin resistance; prehypertension; triglyceride and glucose index; triglyceride to high-density lipoprotein cholesterol ratio; INSULIN-RESISTANCE; SURROGATE; PARAMETERS; PRODUCT; OBESITY; RISK;
D O I
10.1111/jch.14305
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
Insulin resistance (IR) plays an important role in the development of hypertension. Triglyceride and glucose index (TyG index), and triglyceride to high-density lipoprotein cholesterol ratio (TG/HDL-c) as effective IR surrogate indexes have been verified in numerous studies. Therefore, the authors conducted a large cross-sectional study to explore the association of TyG index and TG/HDL-c with prehypertension and hypertension in the same normoglycemic subjects from Tianjin, China. A total of 32 124 adults were eligible for this study. According to the level of blood pressure, the enrolled individuals were divided into three groups, which were normotension, prehypertension, and hypertension. In multiple logistic regression analysis, there was associated with prehypertension and hypertension when comparing the highest TyG index to the lowest TyG index and corresponding ORs were 1.795 (1.638, 1.968) and 2.439 (2.205, 2.698), respectively. For TG/HDL-c, the corresponding ORs were 1.514 (1.382, 1.658) and 1.934 (1.751, 2.137), respectively. Furthermore, when comparing the fourth quartile to the first quartile of TyG index and TG/HDL-c, respectively, both corresponding ORs of hypertension were higher than prehypertension. Elevated TyG index and TG/HDL-c levels were associated with prehypertension and hypertension in normoglycemic individuals. Moreover, the TyG index was more significant than TG/HDL-c in distinguishing hypertension. They have the potential to become cost-effective monitors in the hierarchical management of prehypertension and hypertension.
引用
收藏
页码:1405 / 1412
页数:8
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