Use of peripheral blood DNA for genotype antiretroviral resistance testing in drug-naive HIV-infected subjects

被引：27

作者：

Vicenti, Ilaria ^{[1
]}

Razzolini, Francesca ^{[1
]}

Saladini, Francesco ^{[1
]}

Romano, Laura ^{[1
]}

Zazzi, Maurizio ^{[1
]}

机构：

[1] Univ Siena, Dept Mol Biol, Policlin Le Scotte, Microbiol Sect, I-53100 Siena, Italy

来源：

CLINICAL INFECTIOUS DISEASES | 2007年 / 44卷 / 12期

关键词：

D O I：

10.1086/518287

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Parallel analysis of peripheral blood mononuclear cell DNA and plasma RNA from 169 drug-naive human immunodeficiency virus-infected subjects revealed that evaluation of both compartments increases the sensitivity of detection of drug resistance-related mutations, compared with examination of either source alone. Peripheral blood mononuclear cell DNA may play a role in the surveillance of transmitted antiretroviral resistance.

引用

页码：1657 / 1661

页数：5

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