Possibility of membrane modification as a mechanism of antimony resistance in Leishmania donovani

被引：10
作者：
Kothari, Hema
Kumar, Pranav
Sundar, Shyam
Singh, Neeloo [1 ]
机构：
[1] Cent Drug Res Inst, Drug Target Discovery & Dev Div, Lucknow 226001, Uttar Pradesh, India
[2] Banaras Hindu Univ, Inst Med Sci, Varanasi 221005, Uttar Pradesh, India
来源：
PARASITOLOGY INTERNATIONAL | 2007年 / 56卷 / 01期
关键词：
Leishmania; visceral leishmaniasis (VL); clinical isolates; drug resistance;
D O I：
10.1016/j.parint.2006.10.005
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
Resistance to antimonials has become a clinical threat in the treatment of visceral leishmaniasis (VL). Unravelling the resistance mechanism needs attention to circumvent the problem of drug resistance. In one of the resistant isolates, we earlier identified a gene (PG1) implicated in antimony resistance whose localization in the present study was confirmed on the pellicular plasma membrane of the parasite thereby indicating towards membrane modification as a mechanism of resistance in this resistant isolate. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：77 / 80
页数：4
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