Infectious diseases associated with pediatric type 1 diabetes mellitus: A narrative review

被引：8

作者：

Piccolo, Gianluca ^{[1
,2
]}

De Rose, Elena Lucia ^{[1
]}

Bassi, Marta ^{[1
,3
,5
]}

Napoli, Flavia ^{[3
,5
]}

Minuto, Nicola ^{[3
,4
,5
]}

Maghnie, Mohamad ^{[1
,3
,5
]}

Patti, Giuseppa ^{[1
,3
,5
]}

d'Annunzio, Giuseppe ^{[3
,4
,5
]}

机构：

[1] Univ Genoa, Dept Neurosci Rehabil Ophthalmol Genet Maternal &, Genoa, Italy

[2] IRCCS Ist Giannina Gaslini, Neurooncol Unit, Genoa, Italy

[3] IRCCS Ist Giannina Gaslini, Pediat Clin, Genoa, Italy

[4] IRCCS Ist Giannina Gaslini, Reg Ctr Pediat Diabet, Endocrinol Unit, Genoa, Italy

[5] IRCCS Ist Giannina Gaslini, Endocrinol Unit, Genoa, Italy

来源：

FRONTIERS IN ENDOCRINOLOGY | 2022年 / 13卷

关键词：

diabetes mellitus; children; infections; narrative review; adolescence; immunology; MULTIDRUG-RESISTANT TUBERCULOSIS; HELICOBACTER-PYLORI INFECTION; NECROSIS-FACTOR-ALPHA; ASYMPTOMATIC BACTERIURIA; COMMON INFECTIONS; EMPHYSEMATOUS PYELONEPHRITIS; CUTANEOUS MANIFESTATIONS; ISLET AUTOANTIBODIES; ACUTE APPENDICITIS; ILIOPSOAS ABSCESS;

D O I：

10.3389/fendo.2022.966344

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Diabetes mellitus (DM) has been frequently associated with an impaired immune response against infectious agents, making affected patients at risk for more severe disease and sometimes causing worse outcomes. The recent COVID-19 pandemic has seriously affected patients with both diabetes, in particular those carrying comorbidities or with poor glycemic control. As regards pediatric diabetes mellitus, the availability of more accurate and technological tools for glycemic management and the improved markers of metabolic control might mitigate the negative impact of infections. Notably, good metabolic control of diabetes since its diagnosis reduces not only the risk of microangiopathic complications but also of impaired immune response to infectious diseases. Therefore, vaccinations are strongly recommended. Our paper aims to provide the most updated evidence regarding infectious diseases in type 1 pediatric DM.

引用

页数：11

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