Design of dermal electrospun replacement

Background and Purpose: This study is related to the design of advanced dermal scaffolds (non-woven fibrous mats) to provide multifunctional properties. Materials and Methods: The nanofibre fabric from poly (8-caprolactone) (PCL) solutions in acetone were produced by electrospinning. Based on SEM and its stochastic fibre characterization, equivalent fabric was generated by computer Fibres network was created by random deposition of elastic straight segments within a representative volume element (RVE). Elastic and permeability properties determined experimentally and numerically. Results:The fibres diameter produced fibrous structure depends on solution concentration and electric field, what have been identified by surface response methodology. Effective Young's modules for fibrous network measured and predicted by numerical model depend on fibres density and fibres diameto: Calculated data for permeability and pore distribution were compared with models for fibrous media with acceptable error level. Conclusions: Effective elastic and permeability properties are determined by separate computational models. The scaffold multiscale behaviour is commented with multiphysic design procedure.